Galidesivir hydrochloride - ≥99% , CAS No.222631-44-9

CAS: 222631-44-9 Cat. No.: G650850 Molecular Weight: 301.73 PubChem CID: 69211190

GRADE & PURITY ≥99%

Synonyms

AKOS030526727 | Galidesivir HCl | Galidesivir (hydrochloride) | 1EL1K52SH1 | (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride | (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydro

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV , and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC 50 s ranging from ~3 to ~68 μM

In Vitro

Cellular kinases phosphorylate Galidesivir (BCX4430) hydrochloride to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination. ?\nGalidesivir hydrochloride effectively inhibits the infection of Vero cells with YFV. The EC 50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy . ?\nGalidesivir hydrochloride (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Syrian golden hamsters (hamsters infected with YF virus)Dosage: 4 mg/kg of body weight Administration: I.p.; twice daily for 7 days Result: Significantly improved the survival of hamsters infected with YFV.

Form:Solid

IC50& Target:RdRp inhibitor

Specifications

Synonyms

AKOS030526727 | Galidesivir HCl | Galidesivir (hydrochloride) | 1EL1K52SH1 | (2S, 3S, 4R, 5R)-2-(4-amino-5H-pyrrolo[3, 2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3, 4-diol;hydrochloride | (2S, 3S, 4R, 5R)-2-(4-amino-5H-pyrrolo[3, 2-d]pyrimidin-7-yl)-5-(hydro

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filovir

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1=C(C2=C(N1)C(=NC=N2)N)C3C(C(C(N3)CO)O)O.Cl
• IUPAC Name: (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride
• InChIKey: PCCHVYNGFMEGIG-QPAIBFMUSA-N
• INCHI: 1S/C11H15N5O3.ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);1H/t5-,7+,9-,10+;/m1./s1
• Isomeric SMILES: C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O.Cl
• PubChem CID: 69211190
• Molecular Weight: 301.73

Chemical and Physical Properties

• Solubility: DMSO : 105 mg/mL (347.99 mM; Need ultrasonic) H2O : ≥ 41 mg/mL (135.88 mM)
• Molecular Weight: 301.730 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 301.094 Da
• Monoisotopic Mass: 301.094 Da
• Topological Polar Surface Area: 140.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 333.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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