What dose of antagonist, agonist, or signaling tool should be used in vivo?

What dose of antagonist, agonist, or signaling tool should be used in vivo?

This is complex and depends on a number of factors including the method of administration (intravenous, intramuscular, or intraperitoneal), bioavailability, half-life, rates of hepatic and renal clearance, binding to proteins, drug interactions and tissue-specific distribution and accumulation. As we do not carry out any biological studies of our products in vivo, we therefore recommend that you review the published literature for dosage guidelines.