ELN484228 - 10mM in DMSO , CAS No.312-63-0

CAS: 312-63-0 Cat. No.: E423219 Molecular Weight: 251.28 EC Number: 667-877-5

GRADE & PURITY 10mM in DMSO

Synonyms

N-(4-fluorophenyl)benzenesulfonamide|312-63-0|ELN484228|4'-fluorobenzenesulfonanilide|NSC164389|ELN 484228|Cambridge id 5265852|CBDivE_015342|CHEMBL367580|SCHEMBL2568291|DTXSID40304155|BCP28956|MFCD00091019|s6798|STK401855|AKOS000383212|N-(4-Fluoro-phenyl

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

ELN484228 is a cell-permeable blocker that targetsα-synuclein, a key protein in Parkinson’s disease.

Specifications

Synonyms

N-(4-fluorophenyl)benzenesulfonamide | 312-63-0 | ELN484228 | 4'-fluorobenzenesulfonanilide | NSC164389 | ELN 484228 | Cambridge id 5265852 | CBDivE_015342 | CHEMBL367580 | SCHEMBL2568291 | DTXSID40304155 | BCP28956 | MFCD00091019 | s6798 | STK401855 | AKOS000383212 | N-(4-Fluoro-phenyl

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

ELN484228 is a cell penetrant α-synuclein ligand that rescues of α-synuclein induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction. ELN484228 reverses a-synuclein induced impairment of phagocytosis and protects do

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F
• IUPAC Name: N-(4-fluorophenyl)benzenesulfonamide
• InChIKey: AZORQGXJAXEIGC-UHFFFAOYSA-N
• INCHI: 1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H
• Isomeric SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)F
• Molecular Weight: 251.28
• Reaxy-Rn: 2121725
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2121725&ln=

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: light sensitive
• Molecular Weight: 251.280 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 251.042 Da
• Monoisotopic Mass: 251.042 Da
• Topological Polar Surface Area: 54.600 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 325.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1