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· · COA & SDS available for every product · Same-day shipping on in-stock items BIRT 377 - Moligand™, ≥98%(HPLC) , Inhibitor of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide), CAS No.213211-10-0, Inhibitor of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide)
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC) Synonyms
(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
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Why this grade Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
(5R)-5-[(4-Bromophenyl)methyl]-3-(3, 5-dichlorophenyl)-1, 5-dimethyl-2, 4-imidazolidinedione
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd= 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 pro
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide)
Names and Identifiers Canonical Smiles CC1(C(=O)N(C(=O)N1C)C2=CC(=CC(=C2)Cl)Cl)CC3=CC=C(C=C3)Br IUPAC Name (5R)-5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione InChIKey FJNJHZQMQRVZEE-GOSISDBHSA-N INCHI 1S/C18H15BrCl2N2O2/c1-18(10-11-3-5-12(19)6-4-11)16(24)23(17(25)22(18)2)15-8-13(20)7-14(21)9-15/h3-9H,10H2,1-2H3/t18-/m1/s1 Isomeric SMILES C[C@]1(C(=O)N(C(=O)N1C)C2=CC(=CC(=C2)Cl)Cl)CC3=CC=C(C=C3)Br MeSH Entry Terms (R)-5-(4-bromophenyl)-3-(3,5-dichlorophenyl)-1,5-dimethyl-imidazolidine-2,4-dione;BIRT 377 Molecular Weight 442.13 Reaxy-Rn 46709554 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=46709554&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 44.21, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 22.11, Max Conc. mM: 50 Molecular Weight 442.100 g/mol XLogP3 5.000 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 3 Exact Mass 439.969 Da Monoisotopic Mass 439.969 Da Topological Polar Surface Area 40.600 Ų Heavy Atom Count 25 Formal Charge 0 Complexity 531.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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