UCN-01 - ≥95% (HPLC), high purity , CAS No.112953-11-4, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2;Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of LCK proto-oncogene; Src family ty

Item Number

U138038

Grouped product items
SKU	Size	Availability	Price	Qty
U138038-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,202.90

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Basic Description

Synonyms	BDBM17054 \| NSC638850 \| NSC-638850 \| 7-Hydroxystaurosporine [WHO-DD] \| KRX0601 \| KRX-0601 \| Dietilamina \| Isocyanic acid ethyl ester \| AKOS030230764 \| Anesthenyl \| (+)-UCN-01 \| 1-Ethoxyethylene \| Q27074035 \| (2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl
Specifications & Purity	Moligand™, ≥95%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2;Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of LCK proto-oncogene; Src family ty
Product Description	Description： supplied as：A solution in ethanol Application： UCN 01 is a protein kinase C inhibitor which overrides ZEB1-induced chemoresistance in hepatocellular cancer in human. A cell-permeable Staurosporine derived anticancer agent that inhibits several protein kinases.

Names and Identifiers

IUPAC Name	(2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
INCHI	InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
InChi Key	PBCZSGKMGDDXIJ-HQCWYSJUSA-N
Canonical SMILES	CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
Isomeric SMILES	C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)[C@H](NC6=O)O)NC)OC
WGK Germany	3
PubChem CID	72271
Molecular Weight	482.53

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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2 results found

Lot Number	Certificate Type	Date	Item
G2228211	Certificate of Analysis	May 17, 2024	U138038
G1915206	Certificate of Analysis	Feb 09, 2023	U138038

References

1. Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. (2000) The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.. Cancer Res, 60 (8): (2108-12). [PMID:10786669] [10.1021/op500134e]
2. Sato S, Fujita N, Tsuruo T. (2002) Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).. Oncogene, 21 (11): (1727-38). [PMID:11896604] [10.1021/op500134e]
3. Jiang X, Zhao B, Britton R, Lim LY, Leong D, Sanghera JS, Zhou BB, Piers E, Andersen RJ, Roberge M. (2004) Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.. Mol Cancer Ther, 3 (10): (1221-7). [PMID:15486189] [10.1021/op500134e]
4. Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. (2007) p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.. Cancer Cell, 11 (2): (175-89). [PMID:17292828] [10.1021/op500134e]
5. Takahashi I, Kobayashi E, Asano K, Yoshida M, Nakano H. (1987) UCN-01, a selective inhibitor of protein kinase C from Streptomyces.. J Antibiot, 40 (12): (1782-4). [PMID:3429345] [10.1021/op500134e]
6. Seynaeve CM, Kazanietz MG, Blumberg PM, Sausville EA, Worland PJ. (1994) Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.. Mol Pharmacol, 45 (6): (1207-14). [PMID:8022414] [10.1021/op500134e]

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Basic Description