U-46619 - 98%,10 mg/mL in methyl acetate, high purity , CAS No.56985-40-1, Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor
U-46619 - 98%,10 mg/mL in methyl acetate, high purity , CAS No.56985-40-1, Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Stable thromboxane A2 mimetic and a vasoconstrictor.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Describtion: U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist.
1.Cupitra NI et al.. (2021) Increased receptor expression supports vascular reactivity of the rabbit aorta during preservation.. Eur J Cardiothorac Surg, 59 (3):(680-687). [PMID:33188691]
2.Cupitra NI et al.. (2020) Influence of Ageing on Vascular Reactivity and Receptor Expression in Rabbit Aorta: A Complement to Elastocalcinosis and Smooth Muscle Mechanisms.. Clin Interv Aging, 15 (537-545). [PMID:32368020]
3.Ng HH et al.. (2017) Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes.. Sci Rep, 7 (39604). [PMID:28067255]
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