U-46619 - 98%,10 mg/mL in methyl acetate, high purity , CAS No.56985-40-1, Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor

Item Number
U275847
Grouped product items
SKUSizeAvailabilityPrice Qty
U275847-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$325.90
U275847-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,299.90

Potent thromboxane A 2 agonist

Basic Description

Synonyms11alpha,9alpha-epoxymethano-PGH2 | Hexalan Red 2G | (Z)-7-((1R,4S,5S,6R)-6-((S,E)-3-hydroxyoct-1-enyl)-2-oxabicyclo[2.2.1]heptan-5-yl)hept-5-enoic acid | HMS1989M16 | Brasilan Azo Bordeaux | BSPBio_001534 | 9,11-Dideoxy-11alpha,9alpha-epoxymethanoprostagl
Specifications & PurityMoligand™, ≥98%, 10 mg/mL in methyl acetate
Biochemical and Physiological MechanismsProduct does not compete with ATP. Reversible: no Cell permeable: no Primary Target Stable thromboxane A2 mimetic and a vasoconstrictor.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP receptor;Agonist of IP receptor;Agonist of TP receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Describtion:
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist.

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Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (Z)-7-[(1R,4S,5S,6R)-6-[(E,3S)-3-hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid
INCHI InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
InChi Key LQANGKSBLPMBTJ-BRSNVKEHSA-N
Canonical SMILES CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)CO2)O
Isomeric SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)CO2)O
WGK Germany 2
Alternate CAS 56985-40-1
PubChem CID 5311493
MeSH Entry Terms (15S)-Hydroxy-11 alpha, 9 alpha-(epoxymethano)prosta-5Z, 13E-dienoic Acid;(15S)hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid;11 alpha,9 alpha Epoxymethano PGH2;11 alpha,9 alpha-Epoxymethano PGH2;15-Hydroxy-11 alpha,9 alpha-(epoxymethano)pr
Molecular Weight 350.49

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
B2527600Certificate of AnalysisDec 11, 2024 U275847
B2527601Certificate of AnalysisDec 11, 2024 U275847
B2426261Certificate of AnalysisMar 07, 2024 U275847
B2320635Certificate of AnalysisDec 22, 2023 U275847
B2320589Certificate of AnalysisDec 21, 2022 U275847

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RIDADR UN1231-class3-PG2-Methylacetate,solution

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References

1. Cupitra NI et al..  (2021)  Increased receptor expression supports vascular reactivity of the rabbit aorta during preservation..  Eur J Cardiothorac Surg,  59  (3): (680-687).  [PMID:33188691]
2. Cupitra NI et al..  (2020)  Influence of Ageing on Vascular Reactivity and Receptor Expression in Rabbit Aorta: A Complement to Elastocalcinosis and Smooth Muscle Mechanisms..  Clin Interv Aging,  15  (537-545).  [PMID:32368020]
3. Ng HH et al..  (2017)  Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes..  Sci Rep,  (39604).  [PMID:28067255]

Solution Calculators