| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T423793-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $134.90 |
Anti-inflammatory agent with multiple biological activities
| Synonyms | triptolide | 38748-32-2 | Triptolid | PG490 | NSC 163062 | NSC-163062 | 19ALD1S53J | CHEBI:9747 | CHEMBL463763 | PG-490 | (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one | (3b |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Triptolide inhibits cytokine-induced gene expression via inhibition of NF-κB transcriptional activity. Triptolide induces apoptosis in tumor cells by blocking TNF-α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) indu |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one |
|---|---|
| INCHI | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
| InChi Key | DFBIRQPKNDILPW-CIVMWXNOSA-N |
| Canonical SMILES | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
| Isomeric SMILES | CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C |
| WGK Germany | 3 |
| RTECS | YK7751000 |
| PubChem CID | 107985 |
| Molecular Weight | 360.4 |
| Reaxy-Rn | 1692435 |
| Pictogram(s) | GHS06, GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H301:Toxic if swallowed H300:Fatal if swallowed H330:Fatal if inhaled H300+H330:Fatal if swallowed or if inhaled H361:Suspected of damaging fertility or the unborn child H361f:Suspected of damaging fertility |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P316:Get emergency medical help immediately. |
| WGK Germany | 3 |
| RTECS | YK7751000 |
| Reaxy-Rn | 1692435 |
| Merck Index | 9747 |
| 1. Lin Jingpan, Gao Lu, Lin Yanke, Wang Shuai, Yang Zemin, Ren Shujing, Chen Min, Wu Baojian. (2021) Pharmacokinetics-Based Chronoefficacy of Semen Strychni and Tripterygium Glycoside Tablet Against Rheumatoid Arthritis. Frontiers in Pharmacology, 12 [PMID:34108880] [10.3389/fphar.2021.673263] |
| 2. Zhao Huan, Tong Yongbin, Lu Danyi, Wu Baojian. (2020) Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1854-1864). [PMID:32478421] [10.1111/jphp.13299] |
| 3. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] [10.1038/s42003-019-0607-z] |
| 4. Caili Huang, Tao Zeng, Jiawen Li, Lishan Tan, Xiulong Deng, Yanchao Pan, Qi Chen, Aiqing Li, Jianqiang Hu. (2019) Folate Receptor-Mediated Renal-Targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, 5 (6): (2877–2886). [PMID:33405591] [10.1021/acsbiomaterials.9b00119] |
| 5. Bailing Ma, Mi Lu, Bo-Yang Yu, Jiangwei Tian. (2018) A galactose-mediated targeting nanoprobe for intracellular hydroxyl radical imaging to predict drug-induced liver injury. RSC Advances, 8 (39): (22062-22068). [PMID:35541760] [10.1039/C8RA01424H] |
| 1. Lin Jingpan, Gao Lu, Lin Yanke, Wang Shuai, Yang Zemin, Ren Shujing, Chen Min, Wu Baojian. (2021) Pharmacokinetics-Based Chronoefficacy of Semen Strychni and Tripterygium Glycoside Tablet Against Rheumatoid Arthritis. Frontiers in Pharmacology, 12 [PMID:34108880] [10.3389/fphar.2021.673263] |
| 2. Zhao Huan, Tong Yongbin, Lu Danyi, Wu Baojian. (2020) Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1854-1864). [PMID:32478421] [10.1111/jphp.13299] |
| 3. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] [10.1038/s42003-019-0607-z] |
| 4. Caili Huang, Tao Zeng, Jiawen Li, Lishan Tan, Xiulong Deng, Yanchao Pan, Qi Chen, Aiqing Li, Jianqiang Hu. (2019) Folate Receptor-Mediated Renal-Targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, 5 (6): (2877–2886). [PMID:33405591] [10.1021/acsbiomaterials.9b00119] |
| 5. Bailing Ma, Mi Lu, Bo-Yang Yu, Jiangwei Tian. (2018) A galactose-mediated targeting nanoprobe for intracellular hydroxyl radical imaging to predict drug-induced liver injury. RSC Advances, 8 (39): (22062-22068). [PMID:35541760] [10.1039/C8RA01424H] |
