Tofogliflozin - 97%, high purity , CAS No.903565-83-3, Inhibitor of Sodium/glucose cotransporter 1;Inhibitor of Sodium/glucose cotransporter 2

Item Number

T178116

Grouped product items
SKU	Size	Availability	Price	Qty
T178116-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,051.90

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Basic Description

Synonyms	DTXSID90238097 \| R-7201 \| GTPL9395 \| RO4998452 \| RO-4998452 \| AC-31468 \| C6H18N3OP \| NCGC00485920-01 \| CSG 452 \| deberza \| compound 16d [PMID: 22889351] \| NCGC00257160-01 \| Tofogliflozin [INN] \| A836961 \| BDBM50396779 \| Tofogliflozin anhydrous \| UNII-5542
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Sodium/glucose cotransporter 1;Inhibitor of Sodium/glucose cotransporter 2

Names and Identifiers

IUPAC Name	(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol
INCHI	InChI=1S/C22H26O6/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1
InChi Key	VWVKUNOPTJGDOB-BDHVOXNPSA-N
Canonical SMILES	CCC1=CC=C(C=C1)CC2=CC3=C(COC34C(C(C(C(O4)CO)O)O)O)C=C2
Isomeric SMILES	CCC1=CC=C(C=C1)CC2=CC3=C(CO[C@@]34[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C2
PubChem CID	46908929
Molecular Weight	386.444

References

1. Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Yamaguchi M, Takami K et al.. (2012) Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.. J Med Chem, 55 (17): (7828-40). [PMID:22889351] [10.1021/op500134e]
2. Faillie JL. (2017) Pharmacological aspects of the safety of gliflozins.. Pharmacol Res, 118 (13): (71-81). [PMID:27389050] [10.1021/op500134e]
3. Poole RM, Prossler JE. (2014) Tofogliflozin: first global approval.. Drugs, 74 (8): (939-44). [PMID:24848755] [10.1021/op500134e]

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Basic Description