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Thapsigargin - ≥95%, high purity , CAS No.67526-95-8

3 Citations

Moligand™

≥95%

CAS#: 67526-95-8
Molecular Weight: 650.75
MDL number: MFCD00083511
PubChem CID: 446378

Item Number

T135258

Grouped product items
SKU	Size	Availability	Price
T135258-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
T135258-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$276.90
T135258-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90

Ca 2+ -ATPase inhibitor

View related series

Anti-infection (2806) Apoptosis (1464) Calcium Channel (224) Membrane Transporter/Ion Channel (1831) Neuronal Signaling (3346) SARS-CoV (201)

Basic Description

Synonyms	(-)-Thapsigargin \| NCGC00162381-06 \| Octanoic Acid [3s-[3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy
Specifications & Purity	Moligand™, ≥95%
Biochemical and Physiological Mechanisms	Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemothera
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation. An inducer of stored Ca2+ release.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
INCHI	InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChi Key	IXFPJGBNCFXKPI-FSIHEZPISA-N
Canonical SMILES	CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Isomeric SMILES	CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
WGK Germany	3
PubChem CID	446378
Molecular Weight	650.75

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
L2403115	Certificate of Analysis	Dec 09, 2024	T135258
H2330579	Certificate of Analysis	Aug 17, 2023	T135258
H2330580	Certificate of Analysis	Aug 17, 2023	T135258
I2021077	Certificate of Analysis	Aug 05, 2022	T135258
I2021076	Certificate of Analysis	Aug 05, 2022	T135258
A2309412	Certificate of Analysis	Sep 29, 2021	T135258
K2113551	Certificate of Analysis	Sep 29, 2021	T135258
K2113552	Certificate of Analysis	Sep 29, 2021	T135258
K2113553	Certificate of Analysis	Sep 29, 2021	T135258
L2403116	Certificate of Analysis	Sep 29, 2021	T135258

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P342+P311:IF experiencing respiratory symptoms: Call a POISON CENTER/doctor/...
WGK Germany	3

FAQs and Articles

FAQ

Retinoic Acid and Gene Expression

Categories: Technical articles

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Gao Xiu Kui, Sheng Zu Kang, Lu Ye Hong, Sun Yu Ting, Rao Xi Sheng, Shi Lin Jing, Cong Xiao Xia, Chen Xiao, Wu Hao Bo, Huang Man, Zheng Qiang, Guo Jian-sheng, Jiang Liang Jun, Zheng Li Ling, Zhou Yi Ting. (2023) VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling. Cell Discovery, 9 (1): (1-18). [PMID:37528084] [10.1038/s41421-023-00576-6]
2. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren. (2022) The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 217 (111). [PMID:35764167] [10.1016/j.ijbiomac.2022.06.149]
3. Ziming Zheng, Xianglin Pan, Haoyu Wang, Zhijing Wu, Mitchell A. Sullivan, Yuxuan Liu, Junxi Liu, Kaiping Wang, Yu Zhang. (2021) Mechanism of Lentinan Intestinal Absorption: Clathrin-Mediated Endocytosis and Macropinocytosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (26): (7344–7352). [PMID:34132531] [10.1021/acs.jafc.1c00349]

References

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26. Gu Y et al.. (2016) Porcine Circovirus Type 2 Activates CaMMKß to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium.. Viruses, 8 (5): [PMID:27213427]
27. Zhang M et al.. (2018) Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR.. J Bone Miner Res, [PMID:30496623]
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29. Wendimu MY et al.. (2021) RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.. Cell Signal, 83 (109974). [PMID:33705894]
30. Qiu K et al.. (2022) Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion.. J Anim Sci Biotechnol, 13 (9). [PMID:35144690]
31. Jonas KC et al.. (2018) Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers.. Sci Rep, 8 (2239). [PMID:29396488]
32. Duan J et al.. (2019) The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses.. Nat Commun, 10 (2299). [PMID:31127110]
33. Obiedat A et al.. (2020) The integrated stress response promotes B7H6 expression.. J Mol Med (Berl), 98 (135-148). [PMID:31838577]
34. Thangthaeng N et al.. (2018) Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration.. Nutr Res, 49 (88-95). [PMID:29420996]
35. Gao Xiu Kui, Sheng Zu Kang, Lu Ye Hong, Sun Yu Ting, Rao Xi Sheng, Shi Lin Jing, Cong Xiao Xia, Chen Xiao, Wu Hao Bo, Huang Man, Zheng Qiang, Guo Jian-sheng, Jiang Liang Jun, Zheng Li Ling, Zhou Yi Ting. (2023) VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling. Cell Discovery, 9 (1): (1-18). [PMID:37528084] [10.1038/s41421-023-00576-6]
36. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren. (2022) The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 217 (111). [PMID:35764167] [10.1016/j.ijbiomac.2022.06.149]
37. Ziming Zheng, Xianglin Pan, Haoyu Wang, Zhijing Wu, Mitchell A. Sullivan, Yuxuan Liu, Junxi Liu, Kaiping Wang, Yu Zhang. (2021) Mechanism of Lentinan Intestinal Absorption: Clathrin-Mediated Endocytosis and Macropinocytosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (26): (7344–7352). [PMID:34132531] [10.1021/acs.jafc.1c00349]

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