Tazarotene - ≥98%, high purity , Retinoic acid receptor agonist, CAS No.118292-40-3, Retinoic acid receptor agonist

Item Number
T128058
Grouped product items
SKUSizeAvailabilityPrice Qty
T128058-10mg
10mg
3
$64.90
T128058-50mg
50mg
3
$220.90
T128058-100mg
100mg
3
$351.90
T128058-250mg
250mg
2
$792.90
T128058-1g
1g
2
$2,851.90

Receptor-selective retinoid; binds RAR-β and -γ

Basic Description

Synonyms6-(4,4-Dimethyl-thiochroman-6-ylethynyl)-nicotinic acid ethyl ester | BT164442 | ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate | Fabior (TN) | HMS3747E19 | TAZAROTENE COMPONENT OF DUOBRII | DUOBRII COMPONENT TAZAROTENE | Q3981685
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsReceptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) -βand -γ. Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionRetinoic acid receptor agonist
Product Description

A prodrug for tazarotenic acid with selective affinity for RARβ and RARγ.

AI Insight

Product Properties

ALogP4.9

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid504750881
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750881
IUPAC Name ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
INCHI InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChi Key OGQICQVSFDPSEI-UHFFFAOYSA-N
Canonical SMILES CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
Isomeric SMILES CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
WGK Germany 3
RTECS US5675100
PubChem CID 5381
Molecular Weight 351.46
Reaxy-Rn 8159145

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
K2225760Certificate of AnalysisSep 19, 2024 T128058
K2225763Certificate of AnalysisSep 19, 2024 T128058
K2225764Certificate of AnalysisSep 19, 2024 T128058
K2225765Certificate of AnalysisSep 19, 2024 T128058
K2225766Certificate of AnalysisSep 19, 2024 T128058

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H413:May cause long lasting harmful effects to aquatic life

H361:Suspected of damaging fertility or the unborn child

H362:May cause harm to breast-fed children

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS US5675100
Reaxy-Rn 8159145
Merck Index 9081

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References

1. Charton J, Deprez-Poulain R, Hennuyer N, Tailleux A, Staels B, Deprez B.  (2009)  Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives..  Bioorg Med Chem Lett,  19  (2): (489-92).  [PMID:19058965] [10.1021/op500134e]

Solution Calculators