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Taurocholic Acid - 98%, high purity , CAS No.81-24-3, Inhibitor of OATP1C1;Sodium/bile acid and sulphated solute cotransporter 2

11 Citations

Moligand™

≥98%

CAS#: 81-24-3
Molecular Weight: 515.7
EC Number: 201-336-2,804-788-4
PubChem CID: 6675
PubChem SID: 504751152

Item Number

T336942

Grouped product items
SKU	Size	Availability	Price
T336942-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
T336942-25mg	25mg	3	$246.90
T336942-100mg	100mg	1	$513.90
T336942-250mg	250mg	2	$1,156.90
T336942-1g	1g	2	$4,163.90

a choleretic steroid useful for the quantification of conjugated bile acids

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Endogenous Metabolite (0) Metabolic Enzyme/Protease (0) Sodium/bile acid and sulphated solute cotransporter 2 (0)

Basic Description

Synonyms	Cholic acid taurine conjugate \| N-Choloyltaurine \| N-choloyl-taurine \| Cholaic acid \| 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 24-taurine \| Taurocholate \| TAUROCHOLIC ACID \| NSC25505 \| NSC 25505 \| Acidum cholatauricum \| Cholyltaurine
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of OATP1C1;Sodium/bile acid and sulphated solute cotransporter 2
Product Description	Taurocholic Acid is a choleretic steroid which has been used for the quantification of conjugated bile acids in dried blood spots using electrospray ionization-mass spectrometry. Additionally, its sodium salt can act as a lipase accelerator.

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Product Properties

pKa	pKₐ: 1.42 (Predicted)
Ki Data	Solute carrier organic anion transporter family member 1A1: Ki= 10.8 μM (rat); Solute carrier organic anion transporter family member 1A4: Ki= 39.4 μM (rat); Ileal bile acid transporter: Ki= 41.5 μM (human); Solute carrier organic anion transporter family

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504751152
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504751152
IUPAC Name	2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
INCHI	InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
InChi Key	WBWWGRHZICKQGZ-HZAMXZRMSA-N
Canonical SMILES	CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
Isomeric SMILES	C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C
Alternate CAS	81-24-3,345909-26-4,145-42-6 (mono-hydrochloride salt)
PubChem CID	6675
NSC Number	25505
MeSH Entry Terms	Cholyltaurine;Sodium Taurocholate;Taurine Cholate;Taurocholate;Taurocholate Sodium;Taurocholate, Sodium;Taurocholic Acid;Taurocholic Acid, (5 alpha)-Isomer;Taurocholic Acid, (7 beta)-Isomer;Taurocholic Acid, Monolithium Salt;Taurocholic Acid, Monosodium S
Molecular Weight	515.7

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number	Certificate Type	Date	Item
K2428610	Certificate of Analysis	Nov 15, 2024	T336942
K2428611	Certificate of Analysis	Nov 15, 2024	T336942
K2428612	Certificate of Analysis	Nov 15, 2024	T336942
K2428613	Certificate of Analysis	Nov 15, 2024	T336942
A2303452	Certificate of Analysis	Nov 26, 2022	T336942
A2303453	Certificate of Analysis	Nov 26, 2022	T336942
A2303459	Certificate of Analysis	Nov 26, 2022	T336942
A2303460	Certificate of Analysis	Nov 26, 2022	T336942
A2303658	Certificate of Analysis	Nov 26, 2022	T336942
A2431243	Certificate of Analysis	Nov 26, 2022	T336942
B2426170	Certificate of Analysis	Nov 26, 2022	T336942
C2404195	Certificate of Analysis	Nov 26, 2022	T336942
J2309019	Certificate of Analysis	Nov 26, 2022	T336942

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Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
Merck Index	6.88541666666667

Alternative Products

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wei Jia, Jiying Zhu. (2023) Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (41): (15106–15120). [PMID:37793042] [10.1021/acs.jafc.3c04033]
2. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. (2023) Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes. CELLULAR SIGNALLING, 101 (110508). [PMID:36341984] [10.1016/j.cellsig.2022.110508]
3. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao. (2022) L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (3): (1283-1293). [PMID:36087337] [10.1002/jsfa.12222]
4. Tao Wang, Junjie Han, Huanqin Dai, Jingzu Sun, Jinwei Ren, Wenzhao Wang, Shanshan Qiao, Chang Liu, Li Sun, Shuangjiang Liu, Dianpeng Li, Shenglong Wei, Hongwei Liu. (2022) Polysaccharides from Lyophyllum decastes reduce obesity by altering gut microbiota and increasing energy expenditure. CARBOHYDRATE POLYMERS, 295 (119862). [PMID:35989006] [10.1016/j.carbpol.2022.119862]
5. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei. (2022) Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination. MICROCHIMICA ACTA, 189 (7): (1-8). [PMID:35689150] [10.1007/s00604-022-05338-x]
6. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249]
7. Chen Lirong, Guo Yuqiu, Li Xiaoyue, Gong Kuijie, Liu Kaichang. (2021) Phenolics and related in vitro functional activities of different varieties of fresh waxy corn: a whole grain. BMC Chemistry, 15 (1): (1-9). [PMID:33648574] [10.1186/s13065-021-00740-7]
8. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu. (2021) Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis. PHYTOTHERAPY RESEARCH, 35 (5): (2678-2690). [PMID:33432644] [10.1002/ptr.7014]
9. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao. (2020) Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 187 (113317). [PMID:32416340] [10.1016/j.jpba.2020.113317]
10. Min Gu, Nan Bai, Trond M Kortner. (2017) Taurocholate supplementation attenuates the changes in growth performance, feed utilization, lipid digestion, liver abnormality and sterol metabolism in turbot (Scophthalmus maximus) fed high level of plant protein. AQUACULTURE, 468 (597). [PMID:] [10.1016/j.aquaculture.2016.11.022]
11. Guan-Lin Chen, Song-Gen Chen, Ying-Qing Xie, Fu Chen, Ying-Ying Zhao, Chun-Xia Luo, Yong-Qing Gao. (2015) Total phenolic, flavonoid and antioxidant activity of 23 edible flowers subjected to in vitro digestion. Journal of Functional Foods, 17 (243). [PMID:] [10.1016/j.jff.2015.05.028]

References

1. Wei Jia, Jiying Zhu. (2023) Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (41): (15106–15120). [PMID:37793042] [10.1021/acs.jafc.3c04033]
2. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. (2023) Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes. CELLULAR SIGNALLING, 101 (110508). [PMID:36341984] [10.1016/j.cellsig.2022.110508]
3. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao. (2022) L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (3): (1283-1293). [PMID:36087337] [10.1002/jsfa.12222]
4. Tao Wang, Junjie Han, Huanqin Dai, Jingzu Sun, Jinwei Ren, Wenzhao Wang, Shanshan Qiao, Chang Liu, Li Sun, Shuangjiang Liu, Dianpeng Li, Shenglong Wei, Hongwei Liu. (2022) Polysaccharides from Lyophyllum decastes reduce obesity by altering gut microbiota and increasing energy expenditure. CARBOHYDRATE POLYMERS, 295 (119862). [PMID:35989006] [10.1016/j.carbpol.2022.119862]
5. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei. (2022) Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination. MICROCHIMICA ACTA, 189 (7): (1-8). [PMID:35689150] [10.1007/s00604-022-05338-x]
6. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249]
7. Chen Lirong, Guo Yuqiu, Li Xiaoyue, Gong Kuijie, Liu Kaichang. (2021) Phenolics and related in vitro functional activities of different varieties of fresh waxy corn: a whole grain. BMC Chemistry, 15 (1): (1-9). [PMID:33648574] [10.1186/s13065-021-00740-7]
8. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu. (2021) Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis. PHYTOTHERAPY RESEARCH, 35 (5): (2678-2690). [PMID:33432644] [10.1002/ptr.7014]
9. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao. (2020) Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 187 (113317). [PMID:32416340] [10.1016/j.jpba.2020.113317]
10. Min Gu, Nan Bai, Trond M Kortner. (2017) Taurocholate supplementation attenuates the changes in growth performance, feed utilization, lipid digestion, liver abnormality and sterol metabolism in turbot (Scophthalmus maximus) fed high level of plant protein. AQUACULTURE, 468 (597). [PMID:] [10.1016/j.aquaculture.2016.11.022]
11. Guan-Lin Chen, Song-Gen Chen, Ying-Qing Xie, Fu Chen, Ying-Ying Zhao, Chun-Xia Luo, Yong-Qing Gao. (2015) Total phenolic, flavonoid and antioxidant activity of 23 edible flowers subjected to in vitro digestion. Journal of Functional Foods, 17 (243). [PMID:] [10.1016/j.jff.2015.05.028]

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