| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T421764-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $170.90 |
Potent DPP IV inhibitor; activates NLRP1b inflammasome
| Synonyms | Talabostat mesylate | Talabostat mesilate | Val-boroPro | HY-13233A | SY013378 | Talabostat mesylate; Val-boroPro; PT100 | Talabostatmesylate | AB17749 | EX-A2166 | ((2R)-1-((2S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate | SMR |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Cell permeable: yes Secondary Target QPP, PEP and FAP Primary Target DPP-IV, DPP8 and DPP9 Reversible: yes Target IC50: 15 nM for DPP-II |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| IUPAC Name | [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid;methanesulfonic acid |
|---|---|
| INCHI | InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1 |
| InChi Key | OXYYOEIGQRXGPI-WSZWBAFRSA-N |
| Canonical SMILES | B(C1CCCN1C(=O)C(C(C)C)N)(O)O.CS(=O)(=O)O |
| Isomeric SMILES | B([C@@H]1CCCN1C(=O)[C@H](C(C)C)N)(O)O.CS(=O)(=O)O |
| Alternate CAS | 149682-77-9 |
| PubChem CID | 11522448 |
| Molecular Weight | 310.18 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell. |
| 1. Wang Hao-yu, Lin Xi, Huang Guan-gen, Zhou Rong, Lei Shu-yue, Ren Jing, Zhang Kai-rong, Feng Chun-lan, Wu Yan-wei, Tang Wei. (2023) Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases. ACTA PHARMACOLOGICA SINICA, (1-14). [PMID:36964308] [10.1038/s41401-023-01054-1] |
| 1. Wang Hao-yu, Lin Xi, Huang Guan-gen, Zhou Rong, Lei Shu-yue, Ren Jing, Zhang Kai-rong, Feng Chun-lan, Wu Yan-wei, Tang Wei. (2023) Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases. ACTA PHARMACOLOGICA SINICA, (1-14). [PMID:36964308] [10.1038/s41401-023-01054-1] |
