T0901317 - ≥98%, high purity , CAS No.293754-55-9, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β;Agonist of RAR-related orphan receptor-α;Agonist of RAR-related orphan receptor-γ
T0901317 - ≥98%, high purity , CAS No.293754-55-9, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β;Agonist of RAR-related orphan receptor-α;Agonist of RAR-related orphan receptor-γ
T-0901317 | T 0901317 | N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
T 0901317 is a cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor (LXR) agonist (EC50 of 20 nM for LXRα). T 0901317 is reported to induce the expression of genes associated with fatty acid bi
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Liver X receptor-α;Agonist of Liver X receptor-β;Agonist of RAR-related orphan receptor-α;Agonist of RAR-related orphan receptor-γ
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. A cell-permeable, nonsterol compound that acts as a highly potent LXR activator
1.Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao. (2023) Scavenger receptor-AI targeted theranostic nanoparticles for regression of atherosclerotic plaques via ABCA1 modulation. Nanomedicine-Nanotechnology Biology and Medicine, 50 (102672). [PMID:37044196][10.1016/j.nano.2023.102672]
2.Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu. (2022) Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis. CARBOHYDRATE POLYMERS, 292 (119632). [PMID:35725197][10.1016/j.carbpol.2022.119632]
References
1.Han S, Zhuang H, Shumyak S, Wu J, Xie C, Li H, Yang LJ, Reeves WH. (2018) Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.. Front Immunol, 9 (13):(135). [PMID:29456535][10.1021/op500134e]
2.Wang J, Xiao C, Wei Z, Wang Y, Zhang X, Fu Y. (2018) Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.. Vet Immunol Immunopathol, 197 (13):(87-92). [PMID:29475512][10.1021/op500134e]
3.Zhang CJ et al.. (2021) Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma.. Acta Pharmacol Sin, 42 (9):(1472-1485). [PMID:33303989]
4.Wu D et al.. (2021) Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor a Expression.. Front Aging Neurosci, 13 (634948). [PMID:34045954]
5.Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao. (2023) Scavenger receptor-AI targeted theranostic nanoparticles for regression of atherosclerotic plaques via ABCA1 modulation. Nanomedicine-Nanotechnology Biology and Medicine, 50 (102672). [PMID:37044196][10.1016/j.nano.2023.102672]
6.Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu. (2022) Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis. CARBOHYDRATE POLYMERS, 292 (119632). [PMID:35725197][10.1016/j.carbpol.2022.119632]
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C2404048