SS-208 , CAS No.S613714, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 11;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8

Item Number

S613714

Grouped product items
SKU	Size	Availability	Price	Qty
S613714-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613714-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	SS-208 \| 2245942-72-5 \| 5-[2-[(3,4-Dichlorobenzoyl)amino]ethyl]-N-hydroxy-3-isoxazolecarboxamide \| CHEMBL4469488 \| 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide \| 5-[2-[(3,4-dichlorophenyl)carbonylamino]ethyl]-~{N}-oxidanyl-1,2-oxazole
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 11;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8

Names and Identifiers

INCHI	InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20)
InChi Key	JFGOILLZIAIYGA-UHFFFAOYSA-N
Canonical SMILES	ONC(=O)c1noc(c1)CCNC(=O)c1ccc(c(c1)Cl)Cl
Isomeric SMILES	C1=CC(=C(C=C1C(=O)NCCC2=CC(=NO2)C(=O)NO)Cl)Cl
PubChem CID	135348858

References

1. M L, P PV, T K, M P, E S, J P, K V W, C L, F C, S D et al.. (2016) Essential role of HDAC6 in the regulation of PD-L1 in melanoma.. Mol Oncol, 10 (5): (735-750). [PMID:26775640] [10.1021/op500134e]
2. Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB et al.. (2019) Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.. J Med Chem, 62 (18): (8557-8577). [PMID:31414801] [10.1021/op500134e]

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Basic Description