| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S423881-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
Selective Na+/Ca2+exchange inhibitor (reverse mode)
| Synonyms | SN-6 | 415697-08-4 | SN 6 | 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER | Ethyl 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-1,3-thiazolidine-4-carboxylate | Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50values are 2.9, 16 and 8.6μM for inhibition of intracellular Na+-dependent45Ca2+uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh re |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | SN-6 has been used as a selective Na+/Ca++ exchanger (NCX) inhibitor to study its neuroprotective effects on axonal injury in mice. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | ethyl 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-1,3-thiazolidine-4-carboxylate |
|---|---|
| INCHI | InChI=1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3 |
| InChi Key | ZVYIJXLMBWCGHP-UHFFFAOYSA-N |
| Canonical SMILES | CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-] |
| Isomeric SMILES | CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-] |
| PubChem CID | 10222761 |
| Molecular Weight | 402.46 |
| RIDADR | NONHforallmodesoftransport |
|---|
