| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S422452-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 |
Neutrophil elastase inhibitor
| Synonyms | Sivelestat sodium | 201677-61-4 | Sivelestat sodium tetrahydrate | sivelestat sodium hydrate | Elaspol | ONO-5046.Na | LY544349 Sodium Hydrate | Sivelestat (sodium tetrahydrate) | Sivelestat sodium [USAN] | EI-546 | Ono 5046 | Sivelestat sodium (USAN) | DTXSID0046727 | Sivelestat |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | It is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nm, Ki = 0.2 μ M)。 It also inhibited leukocyte elastase obtained from rabbits, rats, hamsters and mice (IC50 = 19 to 49 nm). But even at 100 μ At m, it also did not inhibit trypsin, |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate;tetrahydrate |
|---|---|
| INCHI | InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1 |
| InChi Key | PLHREJBSQUSUCW-UHFFFAOYSA-M |
| Canonical SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+] |
| Isomeric SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+] |
| PubChem CID | 23663985 |
| Molecular Weight | 528.51 |
