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Silver sulfadiazine - 98%, high purity , Bacterial dihydropteroate synthase inhibitor, CAS No.22199-08-2, Bacterial dihydropteroate synthase inhibitor

7 Citations

≥98%

CAS#: 22199-08-2
Molecular Weight: 357.14
EC Number: 244-834-5
MDL number: MFCD00072101
PubChem CID: 441244
PubChem SID: 488189774

Item Number

S104514

Grouped product items
SKU	Size	Availability	Price
S104514-1g	1g	3	$12.90
S104514-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$49.90
S104514-10g	10g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$88.90
S104514-25g	25g	4	$159.90
S104514-100g	100g	5	$574.90

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Cell Cycle/DNA Damage (0) DNA/RNA Synthesis (0) Pyrimidines (0) Six-Membered Heterocyclic Compounds (0)

Basic Description

Synonyms	4-amino-N-(2-pyrimidinyl) benzenesulfonamide silver salt \| SILVER SULFADIAZINE [GREEN BOOK] \| (4-Amino-N-2-pyrimidinylbenzenesulfonamidato-NN,01)-silver \| RayaSore Kit \| Sildaflo \| SULFADIAZINE SILVER \| N(sup 1)-2-Pyrimidinylsulfanilamide monosilver(1+) s
Specifications & Purity	≥98%
Shipped In	Normal
Action Type	INHIBITOR
Mechanism of action	Bacterial dihydropteroate synthase inhibitor

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488189774
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189774
IUPAC Name	silver;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
INCHI	InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
InChi Key	UEJSSZHHYBHCEL-UHFFFAOYSA-N
Canonical SMILES	C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
Isomeric SMILES	C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
WGK Germany	2
RTECS	WP1950000
PubChem CID	441244
Molecular Weight	357.14
Reaxy-Rn	924042

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
G2115017	Certificate of Analysis	Apr 08, 2025	S104514
A2316013	Certificate of Analysis	Aug 10, 2022	S104514
A2429398	Certificate of Analysis	Aug 10, 2022	S104514
J2219623	Certificate of Analysis	Aug 10, 2022	S104514
J2219630	Certificate of Analysis	Aug 10, 2022	S104514
J2219633	Certificate of Analysis	Aug 10, 2022	S104514
J2219640	Certificate of Analysis	Aug 10, 2022	S104514
J2219641	Certificate of Analysis	Aug 10, 2022	S104514

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	WP1950000
Reaxy-Rn	924042
Merck Index	8903

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Mengying Chen, Huaping Tan, Weijie Xu, Zijia Wang, Jinglei Zhang, Shengke Li, Tianle Zhou, Jianliang li, Xiaohong Niu. (2022) A self-healing, magnetic and injectable biopolymer hydrogel generated by dual cross-linking for drug delivery and bone repair. Acta Biomaterialia, 153 (159). [PMID:36152907] [10.1016/j.actbio.2022.09.036]
2. Sirui He, Jia Liu, Shu He, An Liu, Wei Shao. (2022) Double crosslinked polyvinyl alcohol/gelatin/silver sulfadiazine sponges with excellent antibacterial performance. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 643 (128737). [PMID:] [10.1016/j.colsurfa.2022.128737]
3. Shoukang Du, Xiaojin Chen, Xiaofei Chen, Shengke Li, Guoliang Yuan, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Huaping Tan. (2019) Covalent Chitosan-Cellulose Hydrogels via Schiff-Base Reaction Containing Macromolecular Microgels for pH-Sensitive Drug Delivery and Wound Dressing. MACROMOLECULAR CHEMISTRY AND PHYSICS, 220 (23): (1900399). [PMID:] [10.1002/macp.201900399]
4. Sugunya Potiwiput, Huaping Tan, Guoliang Yuan, Shengke Li, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Xiaohong Hu, Zhonghua Ling, Yong Chen. (2020) Dual-crosslinked alginate/carboxymethyl chitosan hydrogel containing in situ synthesized calcium phosphate particles for drug delivery application. MATERIALS CHEMISTRY AND PHYSICS, 241 (122354). [PMID:] [10.1016/j.matchemphys.2019.122354]
5. Sa Liu, Chunting Zhong, Weiwei Wang, Yongguang Jia, Lin Wang, Li Ren. (2018) α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine. Polymers, 10 (2): (190). [PMID:30966226] [10.3390/polym10020190]
6. Wei Shao, Jimin Wu, Shuxia Wang, Min Huang, Xiufeng Liu, Rui Zhang. (2017) Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings. CARBOHYDRATE POLYMERS, 157 (1963). [PMID:27987918] [10.1016/j.carbpol.2016.11.087]
7. Wei Shao, Hui Liu, Jimin Wu, Shuxia Wang, Xiufeng Liu, Min Huang, Peng Xu. (2016) Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications. Journal of the Taiwan Institute of Chemical Engineers, 63 (404). [PMID:] [10.1016/j.jtice.2016.02.019]

References

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2. F W Fuller,M Parrish,F C Nance. (1994-05-01) A review of the dosimetry of 1% silver sulfadiazine cream in burn wound treatment.. The Journal of burn care & rehabilitation, 15 ((3)): (213-223). [PMID:8056810]
3. S Hoffmann. (1984-01-01) Silver sulfadiazine: an antibacterial agent for topical use in burns. A review of the literature.. Scandinavian journal of plastic and reconstructive surgery, 18 ((1)): (119-126). [PMID:6377481]
4. J Y Chung,M E Herbert. (2001-08-31) Myth: silver sulfadiazine is the best treatment for minor burns.. The Western journal of medicine, 175 ((3)): (205-206). [PMID:11527855]
5. J Dokter,H Boxma,I M M H Oen,M E van Baar,C H van der Vlies. (2012-04-07) Reduction in skin grafting after the introduction of hydrofiber dressings in partial thickness burns: a comparison between a hydrofiber and silver sulphadiazine.. Burns : journal of the International Society for Burn Injuries, 39 ((1)): (130-135). [PMID:22480921]
6. Eric D Roche,Paul J Renick,Shannon P Tetens,Dennis L Carson. (2012-05-31) A model for evaluating topical antimicrobial efficacy against methicillin-resistant Staphylococcus aureus biofilms in superficial murine wounds.. Antimicrobial agents and chemotherapy, 56 ((8)): (4508-4510). [PMID:22644024]
7. Caferi Tayyar Selçuk,Mustafa Durgun,Burhan Ozalp,Alicem Tekin,Recep Tekin,Cemal Akçay,Ulaş Alabalık. (2012-06-13) Comparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumannii.. Burns : journal of the International Society for Burn Injuries, 38 ((8)): (1204-1209). [PMID:22688192]
8. Chia-Yu Chu,Fu-Chuo Peng,Ying-Fang Chiu,Hsing-Chuan Lee,Chien-Wen Chen,Jiun-Chiou Wei,Jiang-Jen Lin. (2012-06-14) Nanohybrids of silver particles immobilized on silicate platelet for infected wound healing.. PloS one, 7 ((6)): (e38360-e38360). [PMID:22693632]
9. Irma M M H Oen,Margriet E van Baar,Esther Middelkoop,Marianne K Nieuwenhuis. (2012-07-31) Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized, controlled trial.. Plastic and reconstructive surgery, 130 ((2)): (274e-283e). [PMID:22842424]
10. Hakan Ocsel,Zafer Teke,Mustafa Sacar,Burhan Kabay,S Ender Duzcan,Inci Gokalan Kara. (2012-08-03) Effects of oriental sweet gum storax on porcine wound healing.. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 25 ((4)): (262-270). [PMID:22853813]
11. Steven L Percival,Katja E Hill,David W Williams,Samuel J Hooper,Dave W Thomas,John W Costerton. (2012-09-19) A review of the scientific evidence for biofilms in wounds.. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 ((5)): (647-657). [PMID:22985037]
12. Jiabin Luan,Jian Wu,Yudong Zheng,Wenhui Song,Guojie Wang,Jia Guo,Xun Ding. (2012-11-28) Impregnation of silver sulfadiazine into bacterial cellulose for antimicrobial and biocompatible wound dressing.. Biomedical materials (Bristol, England), 7 ((6)): (065006-065006). [PMID:23182757]
13. M Prosdocimi,C Bevilacqua. (2012-12-12) Impaired wound healing in diabetes: the rationale for clinical use of hyaluronic acid plus silver sulfadiazine.. Minerva medica, 103 ((6)): (533-539). [PMID:23229372]
14. L P Kamolz,D B Lumenta,M Trop. (2012-12-26) Is there still a need for silver sulfadiazine in small burns?. Burns : journal of the International Society for Burn Injuries, 39 ((3)): (535-536). [PMID:23265279]
15. Luísiane de Ávila Santana,José Marcos Alves,Thiago Antônio Moretti Andrade,João Kazuyuki Kajiwara,Sérgio Britto Garcia,Fernanda Guzzo Gomes,Marco Andrey Cipriani Frade. (2013-01-09) Clinical and immunohistopathological aspects of venous ulcers treatment by Low-Intensity Pulsed Ultrasound (LIPUS).. Ultrasonics, 53 ((4)): (870-879). [PMID:23294989]
16. Henk Hoeksema,David Vandekerckhove,Jozef Verbelen,Alexander Heyneman,Stan Monstrey. (2013-03-26) A comparative study of 1% silver sulphadiazine (Flammazine®) versus an enzyme alginogel (Flaminal®) in the treatment of partial thickness burns.. Burns : journal of the International Society for Burn Injuries, 39 ((6)): (1234-1241). [PMID:23523226]
17. Jason Wasiak,Heather Cleland,Fiona Campbell,Anneliese Spinks. (2013-04-02) Dressings for superficial and partial thickness burns.. The Cochrane database of systematic reviews, 3 ((3)): (CD002106-CD002106). [PMID:23543513]
18. Dong Nyoung Heo,Dae Hyeok Yang,Jung Bok Lee,Min Soo Bae,Jung Ho Kim,Seong Hwan Moon,Heoung Jae Chun,Chun Ho Kim,Ho-Nam Lim,Il Keun Kwon. (2013-04-30) Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.. Journal of biomedical nanotechnology, 9 ((3)): (511-515). [PMID:23621008]
19. Annette Downe. (2013-05-21) Use of Urgotul SSD to reduce bacteria and promote healing in chronic wounds.. British journal of community nursing, (S32-S32). [PMID:23682500]
20. M L Frenia,P Schauben. (1994-06-01) Use of silver sulfadiazine in Stevens-Johnson syndrome.. The Annals of pharmacotherapy, 28 ((6)): (736-737). [PMID:7919562]
21. Frederick W Fuller. (2009-04-08) The side effects of silver sulfadiazine.. Journal of burn care & research : official publication of the American Burn Association, 30 ((3)): (464-470). [PMID:19349889]
22. Andrew C Miller,Rashid M Rashid,Louise Falzon,Elamin M Elamin,Shahriar Zehtabchi. (2010-08-21) Silver sulfadiazine for the treatment of partial-thickness burns and venous stasis ulcers.. Journal of the American Academy of Dermatology, 66 ((5)): (e159-e165). [PMID:20724028]
23. Hua-Liang Li,Li-Ping Chen,Yong-Hua Hu,Yan Qin,Ge Liang,You-Xiong Xiong,Qing-Xi Chen. (2012-03-23) Crocodile oil enhances cutaneous burn wound healing and reduces scar formation in rats.. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 19 ((3)): (265-273). [PMID:22435858]
24. Tamim M Niazi,Te Vuong,Laurant Azoulay,Corrie Marijnen,Kryzstof Bujko,Elie Nasr,Christine Lambert,Marie Duclos,Sergio Faria,Marc David,Bernard Cummings. (2012-06-02) Silver clear nylon dressing is effective in preventing radiation-induced dermatitis in patients with lower gastrointestinal cancer: results from a phase III study.. International journal of radiation oncology, biology, physics, 84 ((3)): (e305-e310). [PMID:22652101]
25. Daniel J Ostlie,David Juang,Pablo Aguayo,Janine P Pettiford-Cunningham,Erin A Erkmann,Diane E Rash,Susan W Sharp,Ronald J Sharp,Shawn D St Peter. (2012-06-19) Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial.. Journal of pediatric surgery, 47 ((6)): (1204-1207). [PMID:22703794]
26. Vincenzina Monzillo,Silvia Corona,Paolo Lanzarini,Claudia Dalla Valle,Piero Marone. (2012-06-19) Chlorhexidine-silver sulfadiazine-impregnated central venous catheters: in vitro antibacterial activity and impact on bacterial adhesion.. The new microbiologica, 35 ((2)): (175-182). [PMID:22707130]
27. Olga Labovitiadi,Andrew J Lamb,Kerr H Matthews. (2012-07-28) In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus.. Therapeutic delivery, 3 ((4)): (443-455). [PMID:22834076]
28. Paritosh Suman,Harikrishnan Ramachandran,Sossy Sahakian,Kamraan Z Gill,Basil A J Horst,Shanta M Modak,Mark A Hardy. (2012-10-12) The use of angiogenic-antimicrobial agents in experimental wounds in animals: problems and solutions.. Annals of the New York Academy of Sciences, 1270 (28-36). [PMID:23050814]
29. Paweł Olczyk,Katarzyna Komosińska-Vassev,Katarzyna Winsz-Szczotka,Ewa M Koźma,Grzegorz Wisowski,Jerzy Stojko,Katarzyna Klimek,Krystyna Olczyk. (2012-11-06) Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing.. Journal of Zhejiang University. Science. B, 13 ((11)): (932-941). [PMID:23125086]
30. Ayse Ebru Sakallioglu Abali,Mehmet Aka,Cem Aydogan,Mehmet Haberal. (2012-11-13) Burns or phytophotodermatitis, abuse or neglect: confusing aspects of skin lesions caused by the superstitious use of fig leaves.. Journal of burn care & research : official publication of the American Burn Association, 33 ((6)): (e309-e312). [PMID:23143617]
31. David J Leaper,Gregory Schultz,Keryln Carville,Jacqueline Fletcher,Theresa Swanson,Rebecca Drake. (2013-01-05) Extending the TIME concept: what have we learned in the past 10 years?().. International wound journal, 9 Suppl 2* (1-19). [PMID:23145905]
32. L I Budkevich,V V Soshkina,T S Astamirova,G V Mirzoian. (2012-12-14) [Modern possibilities of the local treatment of children with burn wounds].. Khirurgiia, (10) ((10)): (48-51). [PMID:23235379]
33. Meenakshi Venkataraman,Mangal Nagarsenker. (2013-01-01) Silver sulfadiazine nanosystems for burn therapy.. AAPS PharmSciTech, 14 ((1)): (254-264). [PMID:23274734]
34. U Sarwar,M Javed,W A Dickson. (2014-02-25) Diagnostic challenges of assessing the depth of burn injuries overlying intricate coloured tattoos.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 67 ((7)): (e186-e187). [PMID:24559732]
35. Mengying Chen, Huaping Tan, Weijie Xu, Zijia Wang, Jinglei Zhang, Shengke Li, Tianle Zhou, Jianliang li, Xiaohong Niu. (2022) A self-healing, magnetic and injectable biopolymer hydrogel generated by dual cross-linking for drug delivery and bone repair. Acta Biomaterialia, 153 (159). [PMID:36152907] [10.1016/j.actbio.2022.09.036]
36. Sirui He, Jia Liu, Shu He, An Liu, Wei Shao. (2022) Double crosslinked polyvinyl alcohol/gelatin/silver sulfadiazine sponges with excellent antibacterial performance. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 643 (128737). [PMID:] [10.1016/j.colsurfa.2022.128737]
37. Shoukang Du, Xiaojin Chen, Xiaofei Chen, Shengke Li, Guoliang Yuan, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Huaping Tan. (2019) Covalent Chitosan-Cellulose Hydrogels via Schiff-Base Reaction Containing Macromolecular Microgels for pH-Sensitive Drug Delivery and Wound Dressing. MACROMOLECULAR CHEMISTRY AND PHYSICS, 220 (23): (1900399). [PMID:] [10.1002/macp.201900399]
38. Sugunya Potiwiput, Huaping Tan, Guoliang Yuan, Shengke Li, Tianle Zhou, Jianliang Li, Yang Jia, Dangsheng Xiong, Xiaohong Hu, Zhonghua Ling, Yong Chen. (2020) Dual-crosslinked alginate/carboxymethyl chitosan hydrogel containing in situ synthesized calcium phosphate particles for drug delivery application. MATERIALS CHEMISTRY AND PHYSICS, 241 (122354). [PMID:] [10.1016/j.matchemphys.2019.122354]
39. Sa Liu, Chunting Zhong, Weiwei Wang, Yongguang Jia, Lin Wang, Li Ren. (2018) α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine. Polymers, 10 (2): (190). [PMID:30966226] [10.3390/polym10020190]
40. Wei Shao, Jimin Wu, Shuxia Wang, Min Huang, Xiufeng Liu, Rui Zhang. (2017) Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings. CARBOHYDRATE POLYMERS, 157 (1963). [PMID:27987918] [10.1016/j.carbpol.2016.11.087]
41. Wei Shao, Hui Liu, Jimin Wu, Shuxia Wang, Xiufeng Liu, Min Huang, Peng Xu. (2016) Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications. Journal of the Taiwan Institute of Chemical Engineers, 63 (404). [PMID:] [10.1016/j.jtice.2016.02.019]

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