SGC-CBP30 - 98%, high purity , CAS No.1613695-14-9, Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300

Item Number

S357869

Grouped product items
SKU	Size	Availability	Price
S357869-5mg	5mg	3	$98.90
S357869-10mg	10mg	3	$147.90
S357869-25mg	25mg	2	$333.90
S357869-50mg	50mg	1	$444.90
S357869-100mg	100mg	1	$751.90

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Basic Description

Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300
Product Description	Product introduction SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects.

Names and Identifiers

Pubchem Sid	504772253
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772253
IUPAC Name	4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
INCHI	InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChi Key	GEPYBHCJBORHCE-SFHVURJKSA-N
Canonical SMILES	CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)CC(C)N5CCOCC5
Isomeric SMILES	CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)C[C@H](C)N5CCOCC5
PubChem CID	72201027
Molecular Weight	509.04

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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5 results found

Lot Number	Certificate Type	Date	Item
G2209334	Certificate of Analysis	Apr 03, 2025	S357869
G2209335	Certificate of Analysis	Apr 03, 2025	S357869
G2209337	Certificate of Analysis	Apr 03, 2025	S357869
G2209338	Certificate of Analysis	Apr 03, 2025	S357869
G2209344	Certificate of Analysis	Apr 03, 2025	S357869

References

1. Hammitzsch A, Tallant C, Fedorov O, O'Mahony A, Brennan PE, Hay DA, Martinez FO, Al-Mossawi MH, de Wit J, Vecellio M et al.. (2015) CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.. Proc Natl Acad Sci USA, 112 (34): (10768-73). [PMID:26261308] [10.1021/op500134e]
2. Chua MJ, Robaa D, Skinner-Adams TS, Sippl W, Andrews KT. (2018) Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites.. Int J Parasitol Drugs Drug Resist, 8 (2): (189-193). [PMID:29631126] [10.1021/op500134e]

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Basic Description