Basic Description

Synonyms	Serotonin hydrochloride \| 153-98-0 \| 5-Hydroxytryptamine hydrochloride \| Serotonin HCl \| 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride \| 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride \| CCRIS 4420 \| UNII-GKN429M9VS \| GKN429M9VS \| 5-HT hydrochloride \| 3-(2-aminoethyl)-1H-
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Endogenous 5-HT receptor agonist. Neurotransmitter involved in diverse physiological functions such as mood, appetite, sleep, sex and temperature in addition to modulating cardiovascular function and the gastrointestinal system.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Serotonin hydrochloride is the salt form of Serotonin, a monoamine neurotransmitter biochemically derived from tryptophan. This neurotransmitter is located in the central nervous system and functions as an endogenous SR (serotonin receptor) agonist in a variety of biochemical processes. In the majority of the human bodies, serotonin is located in enterochromaffin (”Kulchitsky cells”). Serotonin is found in the gastrointestinal tract and platelets. Furthermore, Serotonin functions as a growth factor in some cells and facilitates wound healing in conjunction with platelets. Serotonin is thought to be a key component in the regulation of moods, cognition, and personality traits. As a result, this compound is essential in studying the variations in these traits. A tryptophan based amino acid neurotransmitter.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride
INCHI	InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
InChi Key	MDIGAZPGKJFIAH-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=C1O)C(=CN2)CCN.Cl
Isomeric SMILES	C1=CC2=C(C=C1O)C(=CN2)CCN.Cl
WGK Germany	3
RTECS	NM2571000
PubChem CID	160436
UN Number	2811
Molecular Weight	212.68
Beilstein	3570963
Reaxy-Rn	3570963

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	NM2571000
Reaxy-Rn	3570963
Merck Index	8462

FAQs and Articles

FAQ

Media and Supplements in Cell Culture

Categories: Technical articles

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wenlin Ma, Lihua Pang, Jinhua Liu, Lei Wen, Huili Ma, Yinhui Li, Zhihui Xu, Chengwu Zhang, Hai-Dong Yu. (2023) MnO4–-Triggered Immediate-Stable Real-Time Fluorescence Immunosensor with High Response Speed and Low Steady-State Error. ANALYTICAL CHEMISTRY, 95 (15): (6323–6331). [PMID:37018486] [10.1021/acs.analchem.2c05149]
2. Jiang Mengyuan, Tian Liang, Su Mengjie, Cao Xiaoqing, Jiang Qiyu, Huo Xiaolei, Yu Chunmei. (2022) Real-time monitoring of 5-HT release from cells based on MXene hybrid single-walled carbon nanotubes modified electrode. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (28): (7967-7976). [PMID:36129526] [10.1007/s00216-022-04337-4]
3. Can Chen, Guotong Ruan, Yujie Sun, Lili Wang, Chengwu Zhang, Jinhua Liu. (2021) In situ Cu2+-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application. SENSORS AND ACTUATORS B-CHEMICAL, 346 (130439). [PMID:] [10.1016/j.snb.2021.130439]
4. Han-Yu ZHU, Chao FANG, Wai-Ou ZHAO, Jing-Yuan WANG, Ya-Peng LI. (2020) Synthesis and Characterization of Dual-function H2O2-Responsive Nanoparticles for Drug Delivery to Treat Atherosclerosis. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 48 (e20149). [PMID:] [10.1016/S1872-2040(20)60066-4]
5. Yong-Yi Zhao, Heng Li, Qing-Mei Ge, Hang Cong, Mao Liu, Zhu Tao, Jiang-Lin Zhao. (2020) A chemo-sensor constructed by nanohybrid of multifarene[3,3] and rGO for serotonin hydrochloride with dual response in both fluorescence and voltammetry. MICROCHEMICAL JOURNAL, 158 (105145). [PMID:] [10.1016/j.microc.2020.105145]
6. Qiuyue Sha, Bingyang Sun, Chen Yi, Ruixue Guan, Jian Fei, Zhaoyu Hu, Bifeng Liu, Xin Liu. (2019) A fluorescence turn-on biosensor based on transferrin encapsulated gold nanoclusters for 5-hydroxytryptamine detection. SENSORS AND ACTUATORS B-CHEMICAL, 294 (177). [PMID:] [10.1016/j.snb.2019.05.060]
7. Siyuan Sun, Sisi Zhou, Shaowei Lei, Shujie Zhu, Kai Wang, Huidi Jiang, Hui Zhou. (2019) Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. XENOBIOTICA, 49 (10): (1237-1243). [PMID:30472912] [10.1080/00498254.2018.1542188]
8. Ying Zhang, Wang Ren, Yu Zhu Fan, Jiang Xue Dong, Hui Zhang, Hong Qun Luo, Nian Bing Li. (2019) Label-free fluorescent discrimination and detection of epinephrine and dopamine based on bioinspired in situ copolymers and excitation wavelength switch. ANALYTICA CHIMICA ACTA, 1054 (167). [PMID:30712587] [10.1016/j.aca.2018.12.030]
9. Lisiqi Xie, Xiao Huang, Bin Su. (2017) Portable Sensor for the Detection of Choline and Its Derivatives Based on Silica Isoporous Membrane and Gellified Nanointerfaces. ACS Sensors, 2 (6): (803–809). [PMID:28723110] [10.1021/acssensors.7b00166]
10. Dezhen Wang, Xinru Wang, Ping Zhang, Yao Wang, Renke Zhang, Jin Yan, Zhiqiang Zhou, Wentao Zhu. (2017) The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen. ENVIRONMENTAL POLLUTION, 222 (532). [PMID:28041837] [10.1016/j.envpol.2016.11.028]
11. Hui Mao, Jiachen Liang, Chunguang Ji, Haifeng Zhang, Qi Pei, Yuyang Zhang, Yu Zhang, Yoshio Hisaeda, Xi-Ming Song. (2016) Poly(zwitterionic liquids) functionalized polypyrrole/graphene oxide nanosheets for electrochemically detecting dopamine at low concentration. Materials Science & Engineering C-Materials for Biological Applications, 65 (143). [PMID:27157737] [10.1016/j.msec.2016.04.023]
12. Hui Mao, Haifeng Zhang, Jiachen Liang, Daliang Liu, Shuyao Wu, Yu Zhang, Yuyang Zhang, Qiuhua Wu, Guolin Zhang, Xi-Ming Song. (2015) Preparation of poly(ionic liquids)-functionalized polypyrrole nanotubes and their electrocatalytic application to simultaneously determine dopamine and ascorbic acid. Journal of Materials Chemistry B, 3 (26): (5310-5317). [PMID:32262607] [10.1039/C5TB00259A]
13. Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng, Hui Zhou, Huidi Jiang. (2014) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 49 (1). [PMID:24246570] [10.1016/j.pnpbp.2013.11.005]
14. Yao Wang,Wentao Zhu,Jing Qiu,Xinru Wang,Ping Zhang,Jin Yan,Zhiqiang Zhou. (2015-04-13) Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.. Journal of hazardous materials, 295 (9-16). [PMID:25863579]
15. Jian-Jun Zhong,Ningbo Liao,Tian Ding,Xingqian Ye,Dong-Hong Liu. (2015-07-05) Liquid chromatographic method for toxic biogenic amines in foods using a chaotropic salt.. Journal of chromatography. A, 1406 (331-336). [PMID:26141272]

References

1. Wenlin Ma, Lihua Pang, Jinhua Liu, Lei Wen, Huili Ma, Yinhui Li, Zhihui Xu, Chengwu Zhang, Hai-Dong Yu. (2023) MnO4–-Triggered Immediate-Stable Real-Time Fluorescence Immunosensor with High Response Speed and Low Steady-State Error. ANALYTICAL CHEMISTRY, 95 (15): (6323–6331). [PMID:37018486] [10.1021/acs.analchem.2c05149]
2. Jiang Mengyuan, Tian Liang, Su Mengjie, Cao Xiaoqing, Jiang Qiyu, Huo Xiaolei, Yu Chunmei. (2022) Real-time monitoring of 5-HT release from cells based on MXene hybrid single-walled carbon nanotubes modified electrode. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (28): (7967-7976). [PMID:36129526] [10.1007/s00216-022-04337-4]
3. Can Chen, Guotong Ruan, Yujie Sun, Lili Wang, Chengwu Zhang, Jinhua Liu. (2021) In situ Cu2+-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application. SENSORS AND ACTUATORS B-CHEMICAL, 346 (130439). [PMID:] [10.1016/j.snb.2021.130439]
4. Han-Yu ZHU, Chao FANG, Wai-Ou ZHAO, Jing-Yuan WANG, Ya-Peng LI. (2020) Synthesis and Characterization of Dual-function H2O2-Responsive Nanoparticles for Drug Delivery to Treat Atherosclerosis. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 48 (e20149). [PMID:] [10.1016/S1872-2040(20)60066-4]
5. Yong-Yi Zhao, Heng Li, Qing-Mei Ge, Hang Cong, Mao Liu, Zhu Tao, Jiang-Lin Zhao. (2020) A chemo-sensor constructed by nanohybrid of multifarene[3,3] and rGO for serotonin hydrochloride with dual response in both fluorescence and voltammetry. MICROCHEMICAL JOURNAL, 158 (105145). [PMID:] [10.1016/j.microc.2020.105145]
6. Qiuyue Sha, Bingyang Sun, Chen Yi, Ruixue Guan, Jian Fei, Zhaoyu Hu, Bifeng Liu, Xin Liu. (2019) A fluorescence turn-on biosensor based on transferrin encapsulated gold nanoclusters for 5-hydroxytryptamine detection. SENSORS AND ACTUATORS B-CHEMICAL, 294 (177). [PMID:] [10.1016/j.snb.2019.05.060]
7. Siyuan Sun, Sisi Zhou, Shaowei Lei, Shujie Zhu, Kai Wang, Huidi Jiang, Hui Zhou. (2019) Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. XENOBIOTICA, 49 (10): (1237-1243). [PMID:30472912] [10.1080/00498254.2018.1542188]
8. Ying Zhang, Wang Ren, Yu Zhu Fan, Jiang Xue Dong, Hui Zhang, Hong Qun Luo, Nian Bing Li. (2019) Label-free fluorescent discrimination and detection of epinephrine and dopamine based on bioinspired in situ copolymers and excitation wavelength switch. ANALYTICA CHIMICA ACTA, 1054 (167). [PMID:30712587] [10.1016/j.aca.2018.12.030]
9. Lisiqi Xie, Xiao Huang, Bin Su. (2017) Portable Sensor for the Detection of Choline and Its Derivatives Based on Silica Isoporous Membrane and Gellified Nanointerfaces. ACS Sensors, 2 (6): (803–809). [PMID:28723110] [10.1021/acssensors.7b00166]
10. Dezhen Wang, Xinru Wang, Ping Zhang, Yao Wang, Renke Zhang, Jin Yan, Zhiqiang Zhou, Wentao Zhu. (2017) The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen. ENVIRONMENTAL POLLUTION, 222 (532). [PMID:28041837] [10.1016/j.envpol.2016.11.028]
11. Hui Mao, Jiachen Liang, Chunguang Ji, Haifeng Zhang, Qi Pei, Yuyang Zhang, Yu Zhang, Yoshio Hisaeda, Xi-Ming Song. (2016) Poly(zwitterionic liquids) functionalized polypyrrole/graphene oxide nanosheets for electrochemically detecting dopamine at low concentration. Materials Science & Engineering C-Materials for Biological Applications, 65 (143). [PMID:27157737] [10.1016/j.msec.2016.04.023]
12. Hui Mao, Haifeng Zhang, Jiachen Liang, Daliang Liu, Shuyao Wu, Yu Zhang, Yuyang Zhang, Qiuhua Wu, Guolin Zhang, Xi-Ming Song. (2015) Preparation of poly(ionic liquids)-functionalized polypyrrole nanotubes and their electrocatalytic application to simultaneously determine dopamine and ascorbic acid. Journal of Materials Chemistry B, 3 (26): (5310-5317). [PMID:32262607] [10.1039/C5TB00259A]
13. Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng, Hui Zhou, Huidi Jiang. (2014) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 49 (1). [PMID:24246570] [10.1016/j.pnpbp.2013.11.005]
14. Yao Wang,Wentao Zhu,Jing Qiu,Xinru Wang,Ping Zhang,Jin Yan,Zhiqiang Zhou. (2015-04-13) Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.. Journal of hazardous materials, 295 (9-16). [PMID:25863579]
15. Jian-Jun Zhong,Ningbo Liao,Tian Ding,Xingqian Ye,Dong-Hong Liu. (2015-07-05) Liquid chromatographic method for toxic biogenic amines in foods using a chaotropic salt.. Journal of chromatography. A, 1406 (331-336). [PMID:26141272]

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Serotonin hydrochloride - 10mM in DMSO, high purity , CAS No.153-98-0