SB 328437 (DMSO solution) , CAS No.247580-43-4, Antagonist of CCR3

Item Number

S275358

Grouped product items
SKU	Size	Availability	Price	Qty
S275358-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$187.90
S275358-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$612.90

Highly potent selective CCR3 antagonist

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Basic Description

Synonyms	F81757 \| AKOS040745353 \| HMS3414E05 \| SCHEMBL3930225 \| MS-26166 \| SB 328437 \| L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester \| BDBM50100021 \| DTXSID30440571 \| N-(1-NAPHTHALENYLCARBONYL)-4-NITRO-L-PHENYLALANINE METHYL ESTER \| methyl (2S
Specifications & Purity	Moligand™
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR3
Product Description	Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Names and Identifiers

IUPAC Name	methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
INCHI	InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChi Key	VMFGCGRAIBLAFY-IBGZPJMESA-N
Canonical SMILES	COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
Isomeric SMILES	COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
PubChem CID	10474776
Molecular Weight	378.38

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

References

1. Abonyo BO et al.. (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.. Am J Physiol Lung Cell Mol Physiol, 289 (3): (L478-88). [PMID:15863444]
2. White JR et al.. (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.. J Biol Chem, 275 (47): (36626-31). [PMID:10969084]
3. Mori A et al.. (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.. Int Immunol, 19 (8): (913-21). [PMID:17804691]

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Basic Description