| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S426879-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway
| Synonyms | 912545-86-9 | SAG | smoothened agonist | sag (smo-agonist) | Sag (smo agonist) | SAG (Smo agonist) free base | (Rac)-SAG | SAG dihydrochloride | 4XN97SZK4J | Sag (cyclopamine antagonist) | 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiop |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | 强力平滑（Smo）受体激动剂（Kd = 59 nM）; 拮抗Smo受体上的环巴胺作用。有效激活Shh-light 2细胞（EC50〜3 nM）中的Hedgehog信号通路。独立于Ptch蛋白诱导通路激活。Hedgehog信号传导所需的细胞成分的假定抑制剂。增强iPSC向多巴胺能神经元的神经元分化。 |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| IUPAC Name | 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide |
|---|---|
| INCHI | InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3 |
| InChi Key | VFSUUTYAEQOIMW-UHFFFAOYSA-N |
| Canonical SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl |
| Isomeric SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl |
| Alternate CAS | 912545-86-9 |
| PubChem CID | 5284330 |
| MeSH Entry Terms | SAG 1.1;SAG compound;Smoothened Agonist (SAG) |
| Molecular Weight | 490.06 |
