SAG - 95%, high purity , CAS No.912545-86-9, Agonist of FZD 6;Agonist of SMO

Item Number
S136512
Grouped product items
SKUSizeAvailabilityPrice Qty
S136512-1mg
1mg
2
$58.90
S136512-5mg
5mg
2
$117.90
S136512-10mg
10mg
2
$187.90
S136512-25mg
25mg
2
$345.90
S136512-50mg
50mg
2
$484.90

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Basic Description

Synonyms3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride | GTPL10327 | SAG dihydrochloride, >=98% (HPLC) | BDBM50393851 | 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-y
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent Smoothened (Smo) receptor agonist (Kd= 59 nM); antagonizesCyclopamineaction at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50~ 3 nM). Induces pathway activation independently of Ptch proteins. Putativ
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of FZD 6;Agonist of SMO

AI Insight

Names and Identifiers

Pubchem Sid504763481
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504763481
IUPAC Name 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
INCHI InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3
InChi Key VFSUUTYAEQOIMW-UHFFFAOYSA-N
Canonical SMILES CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
Isomeric SMILES CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
Alternate CAS 912545-86-9
PubChem CID 5284330
MeSH Entry Terms SAG 1.1;SAG compound;Smoothened Agonist (SAG)
Molecular Weight 490.06

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

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5 results found

Lot NumberCertificate TypeDateItem
K2216813Certificate of AnalysisAug 05, 2024 S136512
K2216814Certificate of AnalysisAug 05, 2024 S136512
K2216815Certificate of AnalysisAug 05, 2024 S136512
K2216817Certificate of AnalysisAug 05, 2024 S136512
K2216818Certificate of AnalysisAug 05, 2024 S136512

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References

1. Meerang M et al..  (2016)  Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma..  Mol Cancer Ther,  15  (5): (1095-105).  [PMID:26839306]
2. Yamakawa D et al..  (2022)  Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury..  Adv Sci (Weinh),  10  (e2202632).  [PMID:36373718]
3. Kim BH et al..  (2019)  Deficiency of calpain-6 inhibits primary ciliogenesis..  BMB Rep,  52  (10): (619-624).  [PMID:31619317]
4. Petsouki E et al..  (2021)  FBW7 couples structural integrity with functional output of primary cilia..  Commun Biol,  (1066).  [PMID:34518642]
5. Xing Y et al..  (2016)  Liver X receptor a is essential for the capillarization of liver sinusoidal endothelial cells in liver injury..  Sci Rep,  (21309).  [PMID:26887957]
6. Tessier S et al..  (2019)  NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse\xa0intervertebral disc embryogenesis..  Dev Biol,  455  (2): (369-381).  [PMID:31301300]
7. Yamazoe T et al..  (2020)  Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling..  J Biol Chem,  295  (43): (14723-14736).  [PMID:32820051]
8. Coulter ME et al..  (2018)  The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles..  Cell Rep,  24  (4): (973-986.e8).  [PMID:30044992]
9. May EA et al..  (2021)  Time-resolved proteomics profiling of the ciliary Hedgehog response..  J Cell Biol,  220  (5):   [PMID:33856408]

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