Basic Description

Synonyms	4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione \| 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin) \| 1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,
Specifications & Purity	analytical standard, ≥98%
Biochemical and Physiological Mechanisms	10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.10-Hydroxycamptothecin is an inhibitor of Topo I.DNA topoisomerase I inhibitor (IC 50 = 106 nM). Cytoto
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	analytical standard
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A camptothecin derivative that inhibits DNA topoisomerase I.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
INCHI	InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChi Key	HAWSQZCWOQZXHI-FQEVSTJZSA-N
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
Isomeric SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
RTECS	UQ0491700
PubChem CID	97226
Molecular Weight	364.35
Reaxy-Rn	3019077

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
H2426107	Certificate of Analysis	Aug 31, 2024	H109791
G2222335	Certificate of Analysis	Apr 07, 2024	H109791
I2123008	Certificate of Analysis	Mar 31, 2023	H109791
E1907175	Certificate of Analysis	Dec 13, 2022	H109791
C23161452	Certificate of Analysis	Jun 10, 2022	H109791
G2222336	Certificate of Analysis	Jun 10, 2022	H109791

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
RTECS	UQ0491700
Reaxy-Rn	3019077

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zhou LiPing, Li JiaWei, Yu Bing, Zhang Jun, Hu Hao, Cong HaiLin, Shen YouQing. (2023) The drug loading behavior of PAMAM dendrimer: Insights from experimental and simulation study. Science China-Technological Sciences, 66 (4): (1129-1140). [PMID:] [10.1007/s11431-022-2178-8]
2. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512] [10.3390/pharmaceutics14091765]
3. Shuting Gao, Aying Zhou, Bin Cao, Jing Wang, Fanghua Li, Guosheng Tang, Zhicheng Jiang, Anquan Yang, Ranhua Xiong, Jiandu Lei, Chaobo Huang. (2021) A tunable temperature-responsive and tough platform for controlled drug delivery. NEW JOURNAL OF CHEMISTRY, 45 (29): (13056-13063). [PMID:] [10.1039/D1NJ01356D]
4. Yao Sun, Pengfei Li, Ting Wang, Liting Qin, Gege Cheng, Liqun Shen, Xingdong Yao, Shaoping Wei, Jianxin Jiang, Fuhou Lei. (2019) Alkaloid purification using rosin-based polymer-bonded silica stationary phase in HPLC. JOURNAL OF SEPARATION SCIENCE, 42 (24): (3646-3652). [PMID:31613051] [10.1002/jssc.201900835]
5. Liu Yue, Lu Shan, Zhao Liang, Dong Xin, Zhu Zhenyu, Jin Yongsheng, Chen Haisheng, Lu Feng, Hong Zhanying, Chai Yifeng. (2018) Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (14): (3325-3335). [PMID:29651531] [10.1007/s00216-018-0996-8]
6. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

References

1. Zhou LiPing, Li JiaWei, Yu Bing, Zhang Jun, Hu Hao, Cong HaiLin, Shen YouQing. (2023) The drug loading behavior of PAMAM dendrimer: Insights from experimental and simulation study. Science China-Technological Sciences, 66 (4): (1129-1140). [PMID:] [10.1007/s11431-022-2178-8]
2. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang. (2022) Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy. Pharmaceutics, 14 (9): (1765). [PMID:36145512] [10.3390/pharmaceutics14091765]
3. Shuting Gao, Aying Zhou, Bin Cao, Jing Wang, Fanghua Li, Guosheng Tang, Zhicheng Jiang, Anquan Yang, Ranhua Xiong, Jiandu Lei, Chaobo Huang. (2021) A tunable temperature-responsive and tough platform for controlled drug delivery. NEW JOURNAL OF CHEMISTRY, 45 (29): (13056-13063). [PMID:] [10.1039/D1NJ01356D]
4. Yao Sun, Pengfei Li, Ting Wang, Liting Qin, Gege Cheng, Liqun Shen, Xingdong Yao, Shaoping Wei, Jianxin Jiang, Fuhou Lei. (2019) Alkaloid purification using rosin-based polymer-bonded silica stationary phase in HPLC. JOURNAL OF SEPARATION SCIENCE, 42 (24): (3646-3652). [PMID:31613051] [10.1002/jssc.201900835]
5. Liu Yue, Lu Shan, Zhao Liang, Dong Xin, Zhu Zhenyu, Jin Yongsheng, Chen Haisheng, Lu Feng, Hong Zhanying, Chai Yifeng. (2018) Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (14): (3325-3335). [PMID:29651531] [10.1007/s00216-018-0996-8]
6. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

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SKU	Size	Availability	Price	Qty
H109791-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$123.90
H109791-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$343.90

(S)-10-Hydroxycamptothecin - analytical standard，98%, high purity , CAS No.19685-09-7