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G protein-coupled receptors (GPCRs)
Metabotropic glutamate receptors
Ro 64-5229 - ≥99%(HPLC), high purity , CAS No.246852-46-0, Allosteric modulator of mGlu 2 receptor

Ro 64-5229 - ≥99%(HPLC), high purity , CAS No.246852-46-0, Allosteric modulator of mGlu 2 receptor

Item Number

R288543

Grouped product items
SKU	Size	Availability	Price	Qty
R288543-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$211.90
R288543-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$862.90

Selective, non-competitive mGlu2antagonist

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Basic Description

Synonyms	(Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Selective, non-competitive mGlu2antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50= 0.11μM).
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 2 receptor

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	1-[(Z)-2-cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazole
INCHI	InChI=1S/C17H19Cl2N3O/c18-14-8-5-9-15(19)17(14)16(10-22-12-20-11-21-22)23-13-6-3-1-2-4-7-13/h5,8-13H,1-4,6-7H2/b16-10-
InChi Key	STCVFKBRXOEQRF-YBEGLDIGSA-N
Canonical SMILES	C1CCCC(CC1)OC(=CN2C=NC=N2)C3=C(C=CC=C3Cl)Cl
Isomeric SMILES	C1CCCC(CC1)O/C(=C\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl
PubChem CID	10428048
Molecular Weight	352.26

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