rigosertib , CAS No.592542-59-1

Item Number

R613190

Grouped product items
SKU	Size	Availability	Price	Qty
R613190-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613190-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

Basic Description

Synonyms	BBL010916 \| N-[2-Methoxy-5-({[(E)-2-(2,4,6-Trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine \| RIGOSERTIB [INN] \| DTXSID30207984 \| ON-01910ON-01910 \| MFCD00191660 \| 2-[[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl]amino]
Specifications & Purity	Moligand™
Grade	Moligand™

Names and Identifiers

IUPAC Name	2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetic acid
INCHI	InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11,22H,12-13H2,1-4H3,(H,23,24)/b8-7+
InChi Key	OWBFCJROIKNMGD-BQYQJAHWSA-N
Canonical SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
Isomeric SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
Alternate CAS	592542-59-1
PubChem CID	6918736
MeSH Entry Terms	(N-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetic acid;N-(2-Methoxy-5-((((E)-2-(2,4,6-trimethoxyphenyl)vinyl)sulfonyl)methyl)phenyl)glycine;ON 01910;ON 01910.Na;ON-01910;ON01910;rigosertib;rigosertib sodium;sodium (N-(2-met
Molecular Weight	451.5

References

1. Steegmaier M, Hoffmann M, Baum A, Lénárt P, Petronczki M, Krssák M, Gürtler U, Garin-Chesa P, Lieb S, Quant J et al.. (2007) BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.. Curr Biol, 17 (4): (316-22). [PMID:17291758] [10.1021/op500134e]
2. Lu T, Laughton CA, Wang S, Bradshaw TD. (2015) In vitro antitumor mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide.. Mol Pharmacol, 87 (1): (18-30). [PMID:25316768] [10.1021/op500134e]

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Basic Description