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Remdesivir - ≥98%(HPLC), high purity , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

Moligand™

≥98%(HPLC)

CAS#: 1809249-37-3
Molecular Weight: 602.58
PubChem CID: 121304016
PubChem SID: 504772943

Item Number

R287694

Grouped product items
SKU	Size	Availability	Price
R287694-10mg	10mg	3	$642.90
R287694-50mg	50mg	3	$11.90
R287694-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$18.90
R287694-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$36.90
R287694-500mg	500mg	3	$66.90
R287694-1g	1g	3	$120.90
R287694-5g	5g	2	$423.90
R287694-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,483.90

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucelotide prodrug

View related series

Anti-infection (0) Cell Cycle/DNA Damage (0) CoV RNA-dependent RNA polymerase Inhibitor (0) DNA/RNA Synthesis (0) SARS-CoV (0) SARS-CoV RNA-dependent RNA polymerase Inhibitor (0)

Basic Description

Synonyms	compound 4b [PMID: 28124907] \| SCHEMBL17712225 \| GS5734 \| GS-5734 \| HB9521 \| (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl es
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form,GS 441524. Exhibits activity against a range of RNA virusesin vitro(EC50values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Replicase polyprotein 1ab inhibitor

Names and Identifiers

Pubchem Sid	504772943
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772943
IUPAC Name	2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
INCHI	InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
InChi Key	RWWYLEGWBNMMLJ-YSOARWBDSA-N
Canonical SMILES	CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Isomeric SMILES	CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
PubChem CID	121304016
Molecular Weight	602.58

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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14 results found

Lot Number	Certificate Type	Date	Item
G2411025	Certificate of Analysis	Oct 25, 2023	R287694
G2411041	Certificate of Analysis	Oct 25, 2023	R287694
J2411076	Certificate of Analysis	Oct 25, 2023	R287694
K2310125	Certificate of Analysis	Oct 25, 2023	R287694
K2310126	Certificate of Analysis	Oct 25, 2023	R287694
K2310131	Certificate of Analysis	Oct 25, 2023	R287694
K2310132	Certificate of Analysis	Oct 25, 2023	R287694
K2310133	Certificate of Analysis	Oct 25, 2023	R287694
G2220798	Certificate of Analysis	Jun 16, 2022	R287694
G2220799	Certificate of Analysis	Jun 16, 2022	R287694
G2220800	Certificate of Analysis	Jun 16, 2022	R287694
G2220801	Certificate of Analysis	Jun 16, 2022	R287694
G2220802	Certificate of Analysis	Jun 16, 2022	R287694
G2220804	Certificate of Analysis	Jun 16, 2022	R287694

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Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Siegel D, Hui HC, Doerffler E, Clarke MO, Chun K, Zhang L, Neville S, Carra E, Lew W, Ross B et al.. (2017) Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.. J Med Chem, 60 (5): (1648-1661). [PMID:28124907] [10.1021/op500134e]
2. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I et al.. (2017) Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.. Sci Transl Med, 9 (396): (1755-70). [PMID:28659436] [10.1126/scitranslmed.aal3653]
3. Lamb YN. (2020) Remdesivir: First Approval.. Drugs, 80 (13): (1355-1363). [PMID:32870481] [10.1021/op500134e]
4. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R et al.. (2018) Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.. mBio, 9 (2): (1755-70). [PMID:29511076] [10.1128/mBio.00221-18]
5. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A et al.. (2020) First Case of 2019 Novel Coronavirus in the United States.. N Engl J Med, 382 (10): (929-936). [PMID:32004427] [10.1021/op500134e]
6. Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure FX et al.. (2020) Compassionate Use of Remdesivir for Patients with Severe Covid-19.. N Engl J Med, 382 (24): (2327-2336). [PMID:32275812] [10.1021/op500134e]
7. Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Götte M. (2020) Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.. J Biol Chem, 295 (20): (6785-6797). [PMID:32284326] [10.1021/op500134e]

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Remdesivir - ≥98%(HPLC), high purity , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

Basic Description

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Product Properties

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Show more⌵

Safety and Hazards(GHS)

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References

Solution Calculators

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