Quinacrine dihydrochloride - 10mM in DMSO, high purity , CAS No.69-05-6

Item Number

Q425539

Grouped product items
SKU	Size	Availability	Price	Qty
Q425539-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90

Non-selective phospholipase A 2 inhibitor

View related series

Basic Description

Synonyms	QUINACRINE DIHYDROCHLORIDE \| 69-05-6 \| Quinacrine hydrochloride \| Quinacrine 2HCl \| Mepacrine dihydrochloride \| Atebrine \| Chemiochin \| Quinacrine hydrochloride anhydrous \| Crinodora \| Italchin \| Malaricida \| Methoquine \| Metochin \| Metoquin \| Metoquine \| Palacrin \| Palusan \| Pentilen \| Mec
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	It can be used for female sterilization. For the treatment of systemic lupus erythematosus and rheumatic diseases. Apart from malaria, it is effective for the treatment of Giardia and Taenia infection. Besides inhibiting monoamine oxidase, it can also inh
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Quinacrine dihydrochloride is a non-specific PLA2 (phospholipase A2) inhibitor. Quinacrine, Dihydrochloride acts as an AChR (acetylcholine receptor) antagonist. Quinacrine dihydrochloride suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 μM). This compound also inhibits MAO (monoamine oxidase). Quinacrine, Dihydrochloride is an inhibitor of cPLA2, MAO-A and MAO-B. A non-specific PLA2 inhibitor. and acetylcholine receptor antagonist

Names and Identifiers

IUPAC Name	4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
INCHI	InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChi Key	UDKVBVICMUEIKS-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl
Isomeric SMILES	CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl
WGK Germany	3
RTECS	AR7875000
PubChem CID	6239
Molecular Weight	472.88
Beilstein	4834013
Reaxy-Rn	4834013

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	AR7875000
Reaxy-Rn	4834013
Merck Index	8044

Citations of This Product

1. Siyuan Lu, Jing Chen, Junyuan Wang, Donghui Wu, Hongfeng Bian, Haibo Jiang, Lianxi Sheng, Chunguang He. (2023) Toxicological effects and transcriptome mechanisms of rice (Oryza sativa L.) under stress of quinclorac and polystyrene nanoplastics. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 249 (114380). [PMID:36508812] [10.1016/j.ecoenv.2022.114380]
2. Xiaofei Ma, Jing Cao, Juan Yu, Liangliang Cai. (2022) Evaluation of an ionic liquid chiral selector based on sulfobutylether-β-cyclodextrin in capillary electrophoresis. JOURNAL OF MOLECULAR LIQUIDS, 362 (119782). [PMID:] [10.1016/j.molliq.2022.119782]
3. Ruirui Qi, Yang Su, Leilei Pan, Yuqi Mao, Lu Liang, Zhiqiang Dai, Junqin Wang, Yiling Cai. (2019) Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions. NEUROPHARMACOLOGY, 146 (252). [PMID:30543811] [10.1016/j.neuropharm.2018.12.006]

References

1. Siyuan Lu, Jing Chen, Junyuan Wang, Donghui Wu, Hongfeng Bian, Haibo Jiang, Lianxi Sheng, Chunguang He. (2023) Toxicological effects and transcriptome mechanisms of rice (Oryza sativa L.) under stress of quinclorac and polystyrene nanoplastics. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 249 (114380). [PMID:36508812] [10.1016/j.ecoenv.2022.114380]
2. Xiaofei Ma, Jing Cao, Juan Yu, Liangliang Cai. (2022) Evaluation of an ionic liquid chiral selector based on sulfobutylether-β-cyclodextrin in capillary electrophoresis. JOURNAL OF MOLECULAR LIQUIDS, 362 (119782). [PMID:] [10.1016/j.molliq.2022.119782]
3. Ruirui Qi, Yang Su, Leilei Pan, Yuqi Mao, Lu Liang, Zhiqiang Dai, Junqin Wang, Yiling Cai. (2019) Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions. NEUROPHARMACOLOGY, 146 (252). [PMID:30543811] [10.1016/j.neuropharm.2018.12.006]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description