(–)-PSI Reagent - 95%, high purity , CAS No.2245335-70-8

Item Number

P467206

Grouped product items
SKU	Size	Availability	Price
P467206-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$425.90
P467206-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$981.90
P467206-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,203.90
P467206-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9,608.90

Basic Description

Synonyms	(–)-Ψ, (2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent
Specifications & Purity	≥95%
Legal Information	PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692
Product Description	Description Air- and moisture-tolerant, this (-)-PSI Reagent was developed in theBaran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat#ALD00604).The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by theBaranlab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Names and Identifiers

IUPAC Name	(3aS,6R,7aS)-3a-methyl-2-(2,3,4,5,6-pentafluorophenyl)sulfanyl-6-prop-1-en-2-yl-2-sulfanylidene-5,6,7,7a-tetrahydro-4H-benzo[d][1,3,2]oxathiaphosphole
INCHI	InChI=1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1
InChi Key	YPYCUYPOHPPYAS-QSHUGKRNSA-N
Canonical SMILES	CC(=C)C1CCC2(C(C1)OP(=S)(S2)SC3=C(C(=C(C(=C3F)F)F)F)F)C
PubChem CID	146660239
Molecular Weight	446.46

References

1. Kyle W Knouse, Justine N deGruyter, Michael A Schmidt, Bin Zheng, Julien C Vantourout, Cian Kingston, Stephen E Mercer, Ivar M Mcdonald, Richard E Olson, Ye Zhu, Chao Hang, Jason Zhu, Changxia Yuan, Qinggang Wang, Peter Park, Martin D Eastgate, Phil S Baran,. (2018-08-04) Unlocking P(V): Reagents for chiral phosphorothioate synthesis.. Science (New York, N.Y.), 361 ((6408)): ( 1234-1238 ). [PMID:30072577]

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Basic Description