| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P420585-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 |
| Synonyms | Plerixafor | 110078-46-1 | Mozobil | AMD3100 | 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene | Amd 3100 | bicyclam JM-2987 | SDZ SID 791 | Plerixafor hydrochloride | plerixafor (amd3100) | AMD-3100 | JM3100 | plerixaforum | JKL 169 | JM 3100 | 1-[[4-(1,4,8,11-tetrazacy |
|---|---|
| Specifications & Purity | Moligand™, 2mM in Water |
| Biochemical and Physiological Mechanisms | Plerixafor is a stem cell activator, and CXCR4 chemokine antagonis, Drug treatment of myeloma. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | AGONIST, ANTAGONIST, PARTIAL AGONIST |
| Mechanism of action | C-X-C chemokine receptor type 4 partial agonist |
| Product Description | Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. IC50 value: 44 nM (CXCR4); 5.7 nM (CXCL12-mediated chemotaxis) Target: CXCR4 |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane |
|---|---|
| INCHI | InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2 |
| InChi Key | YIQPUIGJQJDJOS-UHFFFAOYSA-N |
| Canonical SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3 |
| Isomeric SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3 |
| PubChem CID | 65015 |
| Molecular Weight | 502.78 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
| 1. Weizhen Chen, Kui Xu, Bailong Tao, Liangliang Dai, Yonglin Yu, Caiyun Mu, Xinkun Shen, Yan Hu, Ye He, Kaiyong Cai. (2018) Multilayered coating of titanium implants promotes coupled osteogenesis and angiogenesis in vitro and in vivo. Acta Biomaterialia, 74 (489). [PMID:29702291] [10.1016/j.actbio.2018.04.043] |
| 1. Weizhen Chen, Kui Xu, Bailong Tao, Liangliang Dai, Yonglin Yu, Caiyun Mu, Xinkun Shen, Yan Hu, Ye He, Kaiyong Cai. (2018) Multilayered coating of titanium implants promotes coupled osteogenesis and angiogenesis in vitro and in vivo. Acta Biomaterialia, 74 (489). [PMID:29702291] [10.1016/j.actbio.2018.04.043] |
