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Phenylbutazone - ≥98%(HPLC), high purity , CAS No.50-33-9, Inhibitor of COX-1;Inhibitor of COX-2

12 Citations

Moligand™

≥98%(HPLC)

CAS#: 50-33-9
Molecular Weight: 308.37
Beilstein Registry Number: 24(5)5,400
MDL number: MFCD00005500
PubChem CID: 4781
PubChem SID: 488179856

Item Number

P129990

Grouped product items
SKU	Size	Availability	Price
P129990-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
P129990-25g	25g	4	$26.90
P129990-100g	100g	5	$95.90
P129990-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$209.90

Lipophilic NSAID. COX inhibitor.

View related series

COX (0) COX-1 Inhibitor (0) COX-2 Inhibitor (0) Immunology/Inflammation (0)

Basic Description

Synonyms	Lingel \| Butalidon \| Butidiona \| Diozol \| Fenylbutazon \| Tevcodyne \| Artrizin \| Buta phen \| Fenibutol \| Pyrabutol \| Nadazone \| Anerval \| Butapirazol \| Fenartil \| Reupolar \| Butazona \| Butacompren \| Butartrina \| Praecirheumin \| Alindor \| Butagesic \| Nadozo
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of COX-1;Inhibitor of COX-2
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. An inhibitor of Cox.

AI Insight

Names and Identifiers

Pubchem Sid	488179856
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179856
IUPAC Name	4-butyl-1,2-diphenylpyrazolidine-3,5-dione
INCHI	InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
InChi Key	VYMDGNCVAMGZFE-UHFFFAOYSA-N
Canonical SMILES	CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES	CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
WGK Germany	3
RTECS	UQ8225000
PubChem CID	4781
UN Number	2811
Packing Group	I
Molecular Weight	308.37
Beilstein	24(5)5,400
Reaxy-Rn	290080

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
H2406058	Certificate of Analysis	Aug 14, 2024	P129990
G2403650	Certificate of Analysis	Apr 13, 2024	P129990
G2403651	Certificate of Analysis	Apr 13, 2024	P129990
G2403652	Certificate of Analysis	Apr 13, 2024	P129990
L2304026	Certificate of Analysis	Dec 13, 2023	P129990
K2126298	Certificate of Analysis	Sep 20, 2023	P129990
K1710032	Certificate of Analysis	May 10, 2023	P129990
B2315102	Certificate of Analysis	Feb 24, 2023	P129990
F1509094	Certificate of Analysis	Jan 25, 2023	P129990
I2221047	Certificate of Analysis	Sep 26, 2022	P129990

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H351:Suspected of causing cancer H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	UQ8225000
Reaxy-Rn	290080
Class	6.1
Merck Index	7277

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wen Li, Yuzhu Fan, Chaoqun Yan, Yan Du, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li, Taigang Liang. (2022) Triptolide and methotrexate binding competitively to bovine serum albumin: A study of spectroscopic experiments, molecular docking, and molecular dynamic simulation. JOURNAL OF MOLECULAR LIQUIDS, 367 (120300). [PMID:] [10.1016/j.molliq.2022.120300]
2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie. (2022) Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food. Food Bioscience, 49 (101842). [PMID:] [10.1016/j.fbio.2022.101842]
3. Wencheng Zhong, Xiaojian Yan, Shaohua Qu, Li Shang. (2022) Site-specific fabrication of gold nanocluster-based fluorescence photoswitch enabled by the dual roles of albumin proteins. Aggregate, 4 (1): (e245). [PMID:] [10.1002/agt2.245]
4. Fang Huang, Fei Pan, Li Wang, Zhang Xiao, Jinzhao He, Mei Yan, Jia Wang, Weidong Qiu, Mingxue Liu, Haiqing Dong. (2022) The interaction between citronellol and bovine serum albumin: Spectroscopic, computational and thermal imaging studies. JOURNAL OF MOLECULAR STRUCTURE, 1251 (131986). [PMID:] [10.1016/j.molstruc.2021.131986]
5. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun. (2021) Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (30): (7431-7440). [PMID:34676431] [10.1007/s00216-021-03700-1]
6. Yue Wang, Wenchang Zhao, Ruixia Gao, Sameer Hussain, Yi Hao, Jiahao Tian, Shihui Chen, Yunhao Feng, Yubo Zhao, Yuyao Qu. (2022) Preparation of lightweight daisy-like magnetic molecularly imprinted polymers via etching synergized template immobilization for enhanced rapid detection of trace 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 424 (127216). [PMID:34592596] [10.1016/j.jhazmat.2021.127216]
7. Tingting Guo, Xiaojuan Wang, Yang Shu, Jianhua Wang. (2021) Effects of alkyl side-chain length on binding with bovine serum albumin, cytotoxicity, and antibacterial properties of 1-alkyl-3-methylimidazolium dicyanamide ionic liquids. JOURNAL OF MOLECULAR LIQUIDS, 339 (116835). [PMID:] [10.1016/j.molliq.2021.116835]
8. Hui Lv, Juanjuan Wang, Mingying Wang, Li Shen, Ling Xiao, Taijie Chen, Tingzhe Sun, Wenjuan Li, Liangliang Zhu, Xiaoke Zhang. (2021) Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions. FOOD AND CHEMICAL TOXICOLOGY, 149 (112039). [PMID:33549631] [10.1016/j.fct.2021.112039]
9. Xiangyu Cao, Zhijun Yang, Yonglin He, Ying Xia, Yin He, Jianli Liu. (2019) Multispectroscopic exploration and molecular docking analysis on interaction of eriocitrin with bovine serum albumin. JOURNAL OF MOLECULAR RECOGNITION, 32 (7): (e2779). [PMID:30701606] [10.1002/jmr.2779]
10. Miao Qin, Tianxiang Yin, Weiguo Shen. (2016) The Interaction Between Crystal Violet and Bovine Serum Albumin: Spectroscopic and Molecular Docking Investigations. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2015.1073597]
11. Miao Qin, Tianxiang Yin, Shuzhen Wang, Weiguo Shen. (2015) Spectroscopic Investigation on the Interactions between Cationic Surfactants and Bovine Serum Albumin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2014.973031]
12. Wang, et al.. (2021) Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.. Toxicology Letters, 338 (51-57). [PMID:33290829]

References

1. Wen Li, Yuzhu Fan, Chaoqun Yan, Yan Du, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li, Taigang Liang. (2022) Triptolide and methotrexate binding competitively to bovine serum albumin: A study of spectroscopic experiments, molecular docking, and molecular dynamic simulation. JOURNAL OF MOLECULAR LIQUIDS, 367 (120300). [PMID:] [10.1016/j.molliq.2022.120300]
2. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie. (2022) Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food. Food Bioscience, 49 (101842). [PMID:] [10.1016/j.fbio.2022.101842]
3. Wencheng Zhong, Xiaojian Yan, Shaohua Qu, Li Shang. (2022) Site-specific fabrication of gold nanocluster-based fluorescence photoswitch enabled by the dual roles of albumin proteins. Aggregate, 4 (1): (e245). [PMID:] [10.1002/agt2.245]
4. Fang Huang, Fei Pan, Li Wang, Zhang Xiao, Jinzhao He, Mei Yan, Jia Wang, Weidong Qiu, Mingxue Liu, Haiqing Dong. (2022) The interaction between citronellol and bovine serum albumin: Spectroscopic, computational and thermal imaging studies. JOURNAL OF MOLECULAR STRUCTURE, 1251 (131986). [PMID:] [10.1016/j.molstruc.2021.131986]
5. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun. (2021) Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (30): (7431-7440). [PMID:34676431] [10.1007/s00216-021-03700-1]
6. Yue Wang, Wenchang Zhao, Ruixia Gao, Sameer Hussain, Yi Hao, Jiahao Tian, Shihui Chen, Yunhao Feng, Yubo Zhao, Yuyao Qu. (2022) Preparation of lightweight daisy-like magnetic molecularly imprinted polymers via etching synergized template immobilization for enhanced rapid detection of trace 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 424 (127216). [PMID:34592596] [10.1016/j.jhazmat.2021.127216]
7. Tingting Guo, Xiaojuan Wang, Yang Shu, Jianhua Wang. (2021) Effects of alkyl side-chain length on binding with bovine serum albumin, cytotoxicity, and antibacterial properties of 1-alkyl-3-methylimidazolium dicyanamide ionic liquids. JOURNAL OF MOLECULAR LIQUIDS, 339 (116835). [PMID:] [10.1016/j.molliq.2021.116835]
8. Hui Lv, Juanjuan Wang, Mingying Wang, Li Shen, Ling Xiao, Taijie Chen, Tingzhe Sun, Wenjuan Li, Liangliang Zhu, Xiaoke Zhang. (2021) Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions. FOOD AND CHEMICAL TOXICOLOGY, 149 (112039). [PMID:33549631] [10.1016/j.fct.2021.112039]
9. Xiangyu Cao, Zhijun Yang, Yonglin He, Ying Xia, Yin He, Jianli Liu. (2019) Multispectroscopic exploration and molecular docking analysis on interaction of eriocitrin with bovine serum albumin. JOURNAL OF MOLECULAR RECOGNITION, 32 (7): (e2779). [PMID:30701606] [10.1002/jmr.2779]
10. Miao Qin, Tianxiang Yin, Weiguo Shen. (2016) The Interaction Between Crystal Violet and Bovine Serum Albumin: Spectroscopic and Molecular Docking Investigations. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2015.1073597]
11. Miao Qin, Tianxiang Yin, Shuzhen Wang, Weiguo Shen. (2015) Spectroscopic Investigation on the Interactions between Cationic Surfactants and Bovine Serum Albumin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2014.973031]
12. Wang, et al.. (2021) Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.. Toxicology Letters, 338 (51-57). [PMID:33290829]

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