PHA-543613 , Neuronal acetylcholine receptor protein alpha-7 subunit agonist, CAS No.478149-53-0, Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Item Number

P612780

Grouped product items
SKU	Size	Availability	Price
P612780-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$105.90
P612780-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$176.90
P612780-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$379.90
P612780-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$599.90
P612780-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$949.90

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Basic Description

Synonyms	(R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide \| Tox21_300448 \| DTXSID6047284 \| GVVFCAFBYHYGEE-OGFXRTJISA-N \| N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]uro[2,3-c]pyridine-5-carboxamide \| PHA-00543613 \| PHA-543,613 \| CAS-478149-53-0 \| F82142 \| HY-10
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	PHA-543613 exhibits rapid brain penetration property.PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression i
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Neuronal acetylcholine receptor protein alpha-7 subunit agonist
Product Description	PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.

Names and Identifiers

IUPAC Name	N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide
INCHI	InChI=1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
InChi Key	IPKZCLGGYKRDES-ZDUSSCGKSA-N
Canonical SMILES	O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
Isomeric SMILES	C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4
WGK Germany	1
PubChem CID	9930121
Molecular Weight	271.31

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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9 results found

Lot Number	Certificate Type	Date	Item
J2421844	Certificate of Analysis	Sep 13, 2024	P612780
J2421845	Certificate of Analysis	Sep 13, 2024	P612780
J2421846	Certificate of Analysis	Sep 13, 2024	P612780
J2421849	Certificate of Analysis	Sep 13, 2024	P612780
J2421850	Certificate of Analysis	Sep 13, 2024	P612780
J2421858	Certificate of Analysis	Sep 13, 2024	P612780
J2421859	Certificate of Analysis	Sep 13, 2024	P612780
J2421860	Certificate of Analysis	Sep 13, 2024	P612780
J2421861	Certificate of Analysis	Sep 13, 2024	P612780

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1
RIDADR	NONHforallmodesoftransport

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Basic Description