PD0332991 HCl - ≥98%, high purity , CAS No.827022-32-2

Item Number

E129959

Grouped product items
SKU	Size	Availability	Price
E129959-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
E129959-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$82.90
E129959-50mg	50mg	3	$105.90
E129959-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$129.90
E129959-250mg	250mg	2	$292.90

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Basic Description

Synonyms	FT-0700370 \| Palbociclib (hydrochloride) \| PD-0332991 hydrochloride \| AKOS000120736 \| Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-, hydrochloride (1:1) \| MFCD22420809 \| EX-A025 \| 827022-32-2,
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	PD 0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 (IC50’s: Cdk4 = 11 nM; Cdk6 = 16 nM). PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, and IR. PD 0332991 is a non-ATP competitive inhibitor o
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. A highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2.

Names and Identifiers

Pubchem Sid	504766411
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766411
IUPAC Name	6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride
INCHI	InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H
InChi Key	STEQOHNDWONVIF-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
Isomeric SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
PubChem CID	11431660
Molecular Weight	483.99

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
D1625104	Certificate of Analysis	Oct 12, 2023	E129959
K2123044	Certificate of Analysis	Sep 18, 2023	E129959
K2123237	Certificate of Analysis	Sep 18, 2023	E129959
K2123239	Certificate of Analysis	Sep 18, 2023	E129959
G1830083	Certificate of Analysis	Apr 14, 2022	E129959

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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Basic Description