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Panobinostat (LBH589) - ≥98%, high purity , CAS No.404950-80-7, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8;Inhibitor

Moligand™

≥98%

CAS#: 404950-80-7
Molecular Weight: 349.44
PubChem CID: 6918837
PubChem SID: 488195886

Item Number

P125167

Grouped product items
SKU	Size	Availability	Price
P125167-10mg	10mg	4	$64.90
P125167-50mg	50mg	4	$129.90
P125167-100mg	100mg	2	$177.90
P125167-250mg	250mg	3	$400.90

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Anti-infection (0) Apoptosis (0) Autophagy (0) Cell Cycle/DNA Damage (0) Epigenetics (0) HDAC (0) histone deacetylase 1 Inhibitor (0) histone deacetylase 2 Inhibitor (0) histone deacetylase 3 Inhibitor (0) histone deacetylase 4 Inhibitor (0) histone deacetylase 6 Inhibitor (0) histone deacetylase 7 Inhibitor (0) histone deacetylase 8 Inhibitor (0) histone deacetylase 9 Inhibitor (0) HIV (0) m-PEG (0) Plasmodium falciparum histone deacetylase 1 (0)

Basic Description

Synonyms	BCP01816 \| Panobinostat(LBH589) \| AM808102 \| GTPL7489 \| NSC 108217 \| AKOS005146046 \| N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide \| EX-A169 \| NVP-LBH 589 \| 1-Brom-4-methansulfonylbenzen \| EN300-7395075 \| LBH-589B \| N
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several hu
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor of histone deacetylase 8;Inhibitor
Product Description	Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM. Phase 3. An HDAC inhibitor reported to inhibit human multiple myeloma cell lines.

Names and Identifiers

Pubchem Sid	488195886
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195886
IUPAC Name	(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
INCHI	InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChi Key	FPOHNWQLNRZRFC-ZHACJKMWSA-N
Canonical SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
PubChem CID	6918837
Molecular Weight	349.44

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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10 results found

Lot Number	Certificate Type	Date	Item
B2303104	Certificate of Analysis	Nov 13, 2024	P125167
B2303014	Certificate of Analysis	Nov 13, 2024	P125167
B2303098	Certificate of Analysis	Nov 05, 2024	P125167
B2303536	Certificate of Analysis	Nov 05, 2024	P125167
B2303538	Certificate of Analysis	Nov 05, 2024	P125167
B2303539	Certificate of Analysis	Nov 05, 2024	P125167
K2125279	Certificate of Analysis	Sep 11, 2023	P125167
K2125289	Certificate of Analysis	Sep 11, 2023	P125167
K2125291	Certificate of Analysis	Sep 11, 2023	P125167
D1510023	Certificate of Analysis	Nov 16, 2022	P125167

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H301:Toxic if swallowed H331:Toxic if inhaled H373:Causes damage to organs through prolonged or repeated exposure H318:Causes serious eye damage H360:May damage fertility or the unborn child H301+H331:Toxic if swallowed or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.

References

1. Mack GS. (2010) To selectivity and beyond.. Nat Biotechnol, 28 (12): (1259-66). [PMID:21139608] [10.1021/op500134e]
2. Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Skinner-Adams T, Andrews KT. (2015) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.. Int J Parasitol Drugs Drug Resist, 5 (3): (117-26). [PMID:26199860] [10.1021/op500134e]
3. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N et al.. (2008) Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.. Biochem J, 409 (2): (581-9). [PMID:17868033] [10.1021/op500134e]

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Basic Description

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Safety and Hazards(GHS)

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