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Bioactive Small Molecules
Pamufetinib (TAS-115) - 10mM in DMSO, high purity , CAS No.1190836-34-0(DMSO), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Pamufetinib (TAS-115) - 10mM in DMSO, high purity , CAS No.1190836-34-0(DMSO), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Item Number

P580481

Grouped product items
SKU	Size	Availability	Price	Qty
P580481-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90

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Basic Description

Synonyms	TAS115 \| TAS-115 \| GTPL10460 \| N-Propyl acetate LBG-64752 \| pamufetinib \| 6-Quinolinecarboxamide, 4-(2-fluoro-4-((((2-phenylacetyl)amino)thioxomethyl)amino)phenoxy)-7-methoxy-N-methyl- \| AKOS040740129 \| 4-[2-fluoro-4-[[[(2-phenylacetyl)amino]thioxomethyl]
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	TAS-115 is a potent VEGFR and c-Met/HGFR inhibitor, which can inhibit the activities of rVEGFR2 and rMET with IC50 values of 30 and 32 nM, respectively.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	4-[2-fluoro-4-[(2-phenylacetyl)carbamothioylamino]phenoxy]-7-methoxy-N-methylquinoline-6-carboxamide
INCHI	InChI=1S/C27H23FN4O4S/c1-29-26(34)19-14-18-21(15-24(19)35-2)30-11-10-22(18)36-23-9-8-17(13-20(23)28)31-27(37)32-25(33)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,29,34)(H2,31,32,33,37)
InChi Key	ORRNXRYWGDUDOG-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F
Isomeric SMILES	CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F
PubChem CID	44247727
Molecular Weight	518.56

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