OICR 9429 - ≥98%(HPLC), high purity , CAS No.1801787-56-3, Inhibitor of WD repeat domain 5

Item Number

O287472

Grouped product items
SKU	Size	Availability	Price
O287472-5mg	5mg	2	$88.90
O287472-10mg	10mg	1	$137.90
O287472-25mg	25mg	1	$246.90
O287472-50mg	50mg	1	$395.90
O287472-100mg	100mg	1	$632.90

High affinity and selective WDR5 antagonist

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Basic Description

Synonyms	N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide \| OICR-9429 \| 6-Oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-yl
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	High affinity WDR5 antagonist (Kd = 93 nM; IC50 = 64 nM); disrupts WDR5-MLL interaction. Selectivity for WDR5 compared to 22 methyltransferases and a panel of kinases, GPCRs, ion channels and transporters. Reduced viability of acute myeloid leukemia cells
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of WD repeat domain 5

Names and Identifiers

Pubchem Sid	504772628
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772628
IUPAC Name	N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
INCHI	InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
InChi Key	DJOVLOYCGXNVPI-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC=CC(=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
Isomeric SMILES	CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC=CC(=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
PubChem CID	91623360
MeSH Entry Terms	N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-(1,1'-biphenyl)-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide;OICR-9429
Molecular Weight	555.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
I2220531	Certificate of Analysis	Jul 14, 2022	O287472
I2220621	Certificate of Analysis	Jul 14, 2022	O287472
I2220626	Certificate of Analysis	Jul 14, 2022	O287472
I2220627	Certificate of Analysis	Jul 14, 2022	O287472
I2220713	Certificate of Analysis	Jul 14, 2022	O287472

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

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Basic Description