| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| O413939-5mg | 5mg | 3 | $296.90 | |
| O413939-25mg | 25mg | 3 | $1,029.90 | |
| O413939-100mg | 100mg | 3 | $2,437.90 | |
| O413939-500mg | 500mg | 2 | $3,433.90 |
JAK3 Selective Inhibitors
| Synonyms | Oclacitinib (maleate) | BS-44681 | D10142 | N-Methyl[trans-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexyl] methanesulfonamide (2Z)-2-butenedioate | SCHEMBL260868 | AC-32980 | D84061 | AMY19492 | AKOS040759049 | PF 03394197-11 | Disodium ethylen |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Oclacitinib maleate (PF-03394197) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Oclacitinib maleate (PF-03394197) is a novel inhibitor ofJAKfamily members withIC50ranging from 10 to 99 nM and JAK1-dependent cytokines withIC50ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases. Targets JAK1 (Cell-free assay); JAK2 (Cell-free assay); TYK2 (Cell-free assay); JAK3 (Cell-free assay) 10nM; 18nM; 84nM; 99nM In vitro PF-03394197 inhibits JAK family members by 50% at concentrations ranging from 10 to 99 nM and does not inhibit a panel of 38 non-JAK kinases. PF-03394197 is most potent at inhibiting JAK1. PF-03394197 also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. PF-03394197 has minimal effects on cytokines which does not activate the JAK1 enzyme in cells. In vivo PF-03394197 administered orally at a dose of 0.4–0.6 mg/kg twice daily is safe and efficacious in controlling the pruritus associated with allergic dermatitis. PF-03394197 provides itch relief within 24 h that persistes through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7. |
| Pubchem Sid | 504770451 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504770451 |
| IUPAC Name | (Z)-but-2-enedioic acid;N-methyl-1-[4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]methanesulfonamide |
| INCHI | InChI=1S/C15H23N5O2S.C4H4O4/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15;5-3(6)1-2-4(7)8/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChi Key | VQIGDTLRBSNOBV-BTJKTKAUSA-N |
| Canonical SMILES | CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3.C(=CC(=O)O)C(=O)O |
| Isomeric SMILES | CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3.C(=C\C(=O)O)\C(=O)O |
| Alternate CAS | 1208319-27-0 |
| PubChem CID | 44631937 |
| Molecular Weight | 453.51 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 A2309601 | Certificate of Analysis | Oct 10, 2024 | O413939 |
| A2309685 | Certificate of Analysis | Oct 10, 2024 | O413939 |
| A2309686 | Certificate of Analysis | Oct 10, 2024 | O413939 |
| A2309687 | Certificate of Analysis | Oct 10, 2024 | O413939 |
