Skip to the beginning of the images gallery

Obeticholic acid - 98%, high purity , Bile acid receptor FXR agonist, CAS No.459789-99-2, Bile acid receptor FXR agonist

Moligand™

≥98%

CAS#: 459789-99-2
Molecular Weight: 420.63
PubChem CID: 447715
PubChem SID: 504758867

Item Number

I193491

Grouped product items
SKU	Size	Availability	Price
I193491-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$24.90
I193491-50mg	50mg	3	$95.90
I193491-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$342.90
I193491-1g	1g	3	$999.90
I193491-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,496.90

Potent and selective FXR agonist

View related series

Autophagy (0) Farnesoid X receptor Agonist (0) FXR (0) Metabolic Enzyme/Protease (0)

Basic Description

Synonyms	6-ECDCA \| INT-747 \| 6-Ethylchenodeoxycholic acid \| 6-Ethyl-3α,7α-dihydroxycholan-24-oic Acid \| OCA \| (3α,5β, 6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid \| 6a-Ethyl-Chenodeoxycholic Acid
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent and selective FXR agonist (EC 50 = 99 nM). Dual FXR/GP-BAR1 ligand. Induces preadiopocyte differentiation. Induces apoptosis. Shows anticholeretic and anti-inflammatory effects and regulates adipose cell function in vivo. Orally active.Obeticholic
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Bile acid receptor FXR agonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

Pubchem Sid	504758867
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758867
IUPAC Name	(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
INCHI	InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
InChi Key	ZXERDUOLZKYMJM-ZWECCWDJSA-N
Canonical SMILES	CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O
Isomeric SMILES	CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O
PubChem CID	447715
Molecular Weight	420.63

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number	Certificate Type	Date	Item
J2408463	Certificate of Analysis	Aug 01, 2024	I193491
J2408464	Certificate of Analysis	Aug 01, 2024	I193491
D2418382	Certificate of Analysis	Mar 29, 2024	I193491
D2418395	Certificate of Analysis	Mar 29, 2024	I193491
D2418397	Certificate of Analysis	Mar 29, 2024	I193491
D2418438	Certificate of Analysis	Mar 29, 2024	I193491
D2418439	Certificate of Analysis	Mar 29, 2024	I193491
K2302455	Certificate of Analysis	Oct 25, 2023	I193491
K2302461	Certificate of Analysis	Oct 25, 2023	I193491
K2302462	Certificate of Analysis	Oct 25, 2023	I193491
G1929133	Certificate of Analysis	May 06, 2023	I193491
J22111147	Certificate of Analysis	Jun 29, 2022	I193491
J22111197	Certificate of Analysis	Jun 29, 2022	I193491
J2317035	Certificate of Analysis	Jun 29, 2022	I193491
F2218041	Certificate of Analysis	Nov 05, 2021	I193491
F2218042	Certificate of Analysis	Nov 05, 2021	I193491

Show more⌵

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B. (1999) Identification of a nuclear receptor for bile acids.. Science, 284 (5418): (1362-5). [PMID:10334992] [10.1021/op500134e]
2. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. (2001) Nuclear receptors and lipid physiology: opening the X-files.. Science, 294 (5548): (1866-70). [PMID:11729302] [10.1021/op500134e]
3. Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM. (2002) 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.. J Med Chem, 45 (17): (3569-72). [PMID:12166927] [10.1021/op500134e]
4. Gai Z et al.. (2017) Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage.. Sci Rep, 7 (9815). [PMID:28852062]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Obeticholic acid - 98%, high purity , Bile acid receptor FXR agonist, CAS No.459789-99-2, Bile acid receptor FXR agonist

Basic Description

AI Insight

Product Properties

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Show more⌵

Safety and Hazards(GHS)

Related Documents

Alternative Products

FAQs and Articles

Reviews

Customer Reviews

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator