NITD-609 - 97%, high purity , P-type ATPase inhibitor, CAS No.1193314-23-6, P-type ATPase inhibitor

Item Number
N172464
Grouped product items
SKUSizeAvailabilityPrice Qty
N172464-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$44.90
N172464-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$124.90
N172464-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
N172464-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90

Basic Description

SynonymsCipargamin | NITD609 | KAE609
Specifications & PurityMoligand™, ≥97%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionP-type ATPase inhibitor
Product Description

Cipargamin (NITD609) is an potent antimalarial compound, with an IC50 of appr 1 nM against P. falciparum.

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Product Properties

ALogP3.9

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one
INCHI InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1
InChi Key CKLPLPZSUQEDRT-WPCRTTGESA-N
Canonical SMILES CC1CC2=C(C3(N1)C4=C(C=CC(=C4)Cl)NC3=O)NC5=CC(=C(C=C25)F)Cl
Isomeric SMILES C[C@H]1CC2=C([C@]3(N1)C4=C(C=CC(=C4)Cl)NC3=O)NC5=CC(=C(C=C25)F)Cl
PubChem CID 44469321
Molecular Weight 390.24

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
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4 results found

Lot NumberCertificate TypeDateItem
H2419151Certificate of AnalysisMay 07, 2024 N172464
H2419152Certificate of AnalysisMay 07, 2024 N172464
H2419153Certificate of AnalysisMay 07, 2024 N172464
H2419154Certificate of AnalysisMay 07, 2024 N172464

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References

1. Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C et al..  (2010)  Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria..  J Med Chem,  53  (14): (5155-64).  [PMID:20568778] [10.1021/op500134e]
2. Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J et al..  (2010)  Spiroindolones, a potent compound class for the treatment of malaria..  Science,  329  (5996): (1175-80).  [PMID:20813948] [10.1021/op500134e]
3. van Pelt-Koops JC, Pett HE, Graumans W, van der Vegte-Bolmer M, van Gemert GJ, Rottmann M, Yeung BK, Diagana TT, Sauerwein RW.  (2012)  The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector..  Antimicrob Agents Chemother,  56  (7): (3544-8).  [PMID:22508309] [10.1021/op500134e]
4. Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler EA, Diagana TT, Kirk K.  (2013)  Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials..  Cell Host Microbe,  13  (2): (227-37).  [PMID:23414762] [10.1021/op500134e]
5. White NJ, Pukrittayakamee S, Phyo AP, Rueangweerayut R, Nosten F, Jittamala P, Jeeyapant A, Jain JP, Lefèvre G, Li R et al..  (2014)  Spiroindolone KAE609 for falciparum and vivax malaria..  N Engl J Med,  371  (5): (403-10).  [PMID:25075833] [10.1021/op500134e]
6. Stein DS, Jain JP, Kangas M, Lefèvre G, Machineni S, Griffin P, Lickliter J.  (2015)  Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609 (cipargamin) and piperaquine..  Antimicrob Agents Chemother,  59  (6): (3493-500).  [PMID:25845867] [10.1021/op500134e]
7. Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J et al..  (2016)  Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor..  Sci Rep,  (13): (27806).  [PMID:27291296] [10.1021/op500134e]

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