| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M274728-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $128.90 |
Selective, cell-permeable JAK3 inhibitor
| Synonyms | 1-HYDROXY-N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]NAPHTHALENE-2-CARBOXAMIDE | MS1020 | MS-1020 | AKOS040748975 | MS 1020 | NCGC00487351-01 | HY-123099 | CID 73438566 | CS-0081222 | 1255516-86-9 |
|---|---|
| Specifications & Purity | ≥95% |
| Biochemical and Physiological Mechanisms | Selective JAK3 inhibitor. Potently inhibits persistently-active STAT3 in a cell type-specific manner. Downregulates anti-apoptotic gene expression. |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
| IUPAC Name | 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide |
|---|---|
| INCHI | InChI=1S/C21H18N2O3/c24-15-6-8-19-18(11-15)14(12-23-19)9-10-22-21(26)17-7-5-13-3-1-2-4-16(13)20(17)25/h1-8,11-12,23-25H,9-10H2,(H,22,26) |
| InChi Key | KHJNISGKGIHTMY-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=C1)C=CC(=C2O)C(=O)NCCC3=CNC4=C3C=C(C=C4)O |
| Isomeric SMILES | C1=CC=C2C(=C1)C=CC(=C2O)C(=O)NCCC3=CNC4=C3C=C(C=C4)O |
| PubChem CID | 73438566 |
| Molecular Weight | 346.38 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |
