MMV-390048 - 97%, high purity , CAS No.1314883-11-8

Item Number

M173331

Grouped product items
SKU	Size	Availability	Price
M173331-1mg	1mg	3	$39.90
M173331-5mg	5mg	3	$162.90
M173331-25mg	25mg	3	$543.90
M173331-50mg	50mg	2	$870.90
M173331-100mg	100mg	2	$1,360.90

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Basic Description

Synonyms	0Z5T00JJ10 \| AKOS030628490 \| SCHEMBL2225969 \| 3-(2-(Trifluoromethyl)pyridin-5-yl)-5-(4-(methylsulfonyl)- phenyl)pyridin-2-amine \| MMV390048 \| MMV-390048 \| J3.367.891F \| HY-106005 \| 5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Product Describtion: MMV-390048, an antimalarial agent, is an inhibitor of Plasmodium PI4K with Kd of 0.3 μM.

Names and Identifiers

Pubchem Sid	504771141
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771141
IUPAC Name	5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
INCHI	InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
InChi Key	RTJQABCNNLMCJF-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F
Isomeric SMILES	CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F
PubChem CID	53311393
Molecular Weight	393.383

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
C2209178	Certificate of Analysis	Dec 06, 2024	M173331
C2209593	Certificate of Analysis	Dec 06, 2024	M173331
C2209594	Certificate of Analysis	Dec 06, 2024	M173331
C2209597	Certificate of Analysis	Dec 06, 2024	M173331
C2209598	Certificate of Analysis	Dec 06, 2024	M173331

References

1. Younis Y, Douelle F, Feng TS, González Cabrera D, Le Manach C, Nchinda AT, Duffy S, White KL, Shackleford DM, Morizzi J et al.. (2012) 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.. J Med Chem, 55 (7): (3479-87). [PMID:22390538] [10.1021/op500134e]
2. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.. Sci Transl Med, 9 (387): (1755-70). [PMID:28446690] [10.1021/op500134e]
3. McCarthy JS, Donini C, Chalon S, Woodford J, Marquart L, Collins KA, Rozenberg FD, Fidock DA, Cherkaoui-Rbati MH, Gobeau N et al.. (2020) A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.. Clin Infect Dis, 71 (10): (e657-e664). [PMID:32239164] [10.1021/op500134e]
4. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria.. Nature, 504 (7479): (248-253). [PMID:24284631] [10.1021/op500134e]

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Basic Description