LY 2955303 - ≥98%(HPLC), high purity , CAS No.1433497-19-8

Item Number

L287287

Grouped product items
SKU	Size	Availability	Price
L287287-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$24.90
L287287-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$73.90
L287287-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$132.90
L287287-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$297.90
L287287-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$536.90
L287287-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$966.90

High affinity and selective RARγ antagonist

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Basic Description

Synonyms	4-[5-[3,5-bis(1,1-Dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-benzoi acid
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	High affinity and selective RARγ antagonist (Kivalues are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	LY2955303 is a potent and selective antagonist of retinoic acid receptor γ (RARγ) with a Ki value of 1.09 nM

Names and Identifiers

IUPAC Name	4-[5-(3,5-ditert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyrazol-3-yl]benzoic acid
INCHI	InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43)
InChi Key	YVXYHNKIOFSFMZ-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C
Isomeric SMILES	CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C
PubChem CID	71552369
Molecular Weight	578.74

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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12 results found

Lot Number	Certificate Type	Date	Item
I2413314	Certificate of Analysis	Jun 19, 2024	L287287
I2413315	Certificate of Analysis	Jun 19, 2024	L287287
I2413419	Certificate of Analysis	Jun 19, 2024	L287287
I2413420	Certificate of Analysis	Jun 19, 2024	L287287
I2413421	Certificate of Analysis	Jun 19, 2024	L287287
I2413422	Certificate of Analysis	Jun 19, 2024	L287287
I2413423	Certificate of Analysis	Jun 19, 2024	L287287
I2413424	Certificate of Analysis	Jun 19, 2024	L287287
I2413425	Certificate of Analysis	Jun 19, 2024	L287287
I2413426	Certificate of Analysis	Jun 19, 2024	L287287
I2413427	Certificate of Analysis	Jun 19, 2024	L287287
I2413428	Certificate of Analysis	Jun 19, 2024	L287287

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Basic Description