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Losartan - 10mM in DMSO, high purity , CAS No.114798-26-4, Antagonist of AT 1 receptor

6 Citations
Item Number
L420721
Grouped product items
SKUSizeAvailabilityPrice Qty
L420721-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$103.90
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an AT1 inhibitor which prevents the initiation of a signal cascade which causes vasoconstriction

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Compound libraries (0)

Basic Description

Synonymslosartan | 114798-26-4 | DUP 89 | allisartan | Angizaar | Losartic | Hyzaar | Cozaar | Lozap | LOSARTAN POTASSIUM | CHEBI:6541 | DUP-89 | DTXSID7023227 | UNII-JMS50MPO89 | JMS50MPO89 | Losartan (INN) | NSC-758699 | HGP1405 | HGP-1405 | DuP-753 | (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen
Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological MechanismsLosartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of AT 1 receptor
Product Description

Losartan is a potent, non-peptide antagonist of angiotensin II receptor, type 1 (AT1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.

AI Insight

Names and Identifiers

IUPAC Name [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
INCHI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChi Key PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Canonical SMILES CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Isomeric SMILES CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Alternate CAS 114798-26-4,124750-99-8 (mono-potassium salt)
PubChem CID 3961
NSC Number 758699
MeSH Entry Terms 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;Cozaar;DuP 753;DuP-753;DuP753;Losartan;Losartan Monopotassium Salt;Losartan Potassium;MK 954;MK-954;MK954;Monopotassium Salt, Losartan;Potassium, Losartan;Salt,
Molecular Weight 422.92

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H413:May cause long lasting harmful effects to aquatic life

H317:May cause an allergic skin reaction

H360:May damage fertility or the unborn child

H362:May cause harm to breast-fed children

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Reviews

Customer Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo.  (2024)  Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  126  (17): (105825).  [PMID:17580304] [10.1016/j.jfca.2023.105825]
2. Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou.  (2023)  Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy.  Small Methods,  7  (5): (2201327).  [PMID:37075716] [10.1002/smtd.202201327]
3. Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo, Yifeng Lei.  (2023)  Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars.  Biomaterials Science,  11  (2): (583-595).  [PMID:36475528] [10.1039/D2BM01631A]
4. Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao.  (2023)  Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  300  (115705).  [PMID:36099983] [10.1016/j.jep.2022.115705]
5. Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao.  (2022)  Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method.  CHROMATOGRAPHIA,  85  (3): (221-231).  [PMID:] [10.1007/s10337-021-04126-8]
6. Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang.  (2021)  Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats.  JOURNAL OF ETHNOPHARMACOLOGY,  281  (114521).  [PMID:34390794] [10.1016/j.jep.2021.114521]

References

1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo.  (2024)  Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  126  (17): (105825).  [PMID:17580304] [10.1016/j.jfca.2023.105825]
2. Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou.  (2023)  Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy.  Small Methods,  7  (5): (2201327).  [PMID:37075716] [10.1002/smtd.202201327]
3. Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo, Yifeng Lei.  (2023)  Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars.  Biomaterials Science,  11  (2): (583-595).  [PMID:36475528] [10.1039/D2BM01631A]
4. Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao.  (2023)  Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  300  (115705).  [PMID:36099983] [10.1016/j.jep.2022.115705]
5. Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao.  (2022)  Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method.  CHROMATOGRAPHIA,  85  (3): (221-231).  [PMID:] [10.1007/s10337-021-04126-8]
6. Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang.  (2021)  Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats.  JOURNAL OF ETHNOPHARMACOLOGY,  281  (114521).  [PMID:34390794] [10.1016/j.jep.2021.114521]

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