Lofepramine - 97%, high purity , CAS No.23047-25-8, Inhibitor of NET;Inhibitor of SERT

Item Number

L287104

Grouped product items
SKU	Size	Availability	Price
L287104-5mg	5mg	3	$92.90
L287104-10mg	10mg	3	$141.90
L287104-25mg	25mg	2	$318.90
L287104-50mg	50mg	2	$574.90
L287104-100mg	100mg	2	$1,034.90

5-HT and NA reuptake inhibitor (SNRI)

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Basic Description

Synonyms	1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamino}ethanone \| Gamanil \| HMS3413F21 \| Lopramine \| J-014957 \| DB 2182 \| Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]- \| Lof
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activityin vitroand displays antidepressant propertiesin vivo.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of NET;Inhibitor of SERT
Product Description	Product Describtion: Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.

Names and Identifiers

Pubchem Sid	488179810
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179810
IUPAC Name	1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
INCHI	InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
InChi Key	SAPNXPWPAUFAJU-UHFFFAOYSA-N
Canonical SMILES	CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
Isomeric SMILES	CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
PubChem CID	3947
Molecular Weight	418.97

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
F2330735	Certificate of Analysis	Apr 27, 2023	L287104
F2330736	Certificate of Analysis	Apr 27, 2023	L287104
F2330740	Certificate of Analysis	Apr 27, 2023	L287104
F2330741	Certificate of Analysis	Apr 27, 2023	L287104
F2330742	Certificate of Analysis	Apr 27, 2023	L287104
F2330743	Certificate of Analysis	Apr 27, 2023	L287104
F2330744	Certificate of Analysis	Apr 27, 2023	L287104
F2330746	Certificate of Analysis	Apr 27, 2023	L287104
F2330747	Certificate of Analysis	Apr 27, 2023	L287104
F2330755	Certificate of Analysis	Apr 27, 2023	L287104

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H336:May cause drowsiness or dizziness H370:Causes damage to organs
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P319:Get medical help if you feel unwell.

References

1. Sánchez C, Hyttel J. (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.. Cell Mol Neurobiol, 19 (4): (467-89). [PMID:10379421] [10.1021/op500134e]
2. Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997) Pharmacological profile of antidepressants and related compounds at human monoamine transporters.. Eur J Pharmacol, 340 (2-3): (249-58). [PMID:9537821] [10.1021/op500134e]

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Basic Description