Liproxstatin-1 - 10mM in DMSO, high purity , CAS No.950455-15-9(DMSO)

Item Number

L407981

• Synonyms: N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

Liproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).

In vivo

Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
Cell Data

cell lines：Dendritic cells (DCs) and CD4+ T cells

Concentrations：~200 nM

Incubation Time：~72 h

Powder Purity:≥97%