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Basic Description
| Synonyms | 2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid | Glycine-linoleamide | SCHEMBL6681636 | NCGC00161201-06 | HMS1791I08 | IDI1_033916 | NCGC00161201-05 | J-016835 | linolyl glycine | HMS1361I08 | BRD-K76293260-001-02-6 | ((9Z,12Z)-Octadeca-9,12-dienoyl |
|---|---|
| Specifications & Purity | ≥97% |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC|50|~ 25 μM), which is less potent than that of arachidonyl glycine (IC|50|= 7 μM). The biological significance of linoleoyl glycine has not yet been determined. |
AI Insight
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 504764150 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764150 |
| IUPAC Name | 2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid |
| INCHI | InChI=1S/C20H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(22)21-18-20(23)24/h6-7,9-10H,2-5,8,11-18H2,1H3,(H,21,22)(H,23,24)/b7-6-,10-9- |
| InChi Key | YCRHZEHWEYAHCO-HZJYTTRNSA-N |
| Canonical SMILES | CCCCCC=CCC=CCCCCCCCC(=O)NCC(=O)O |
| Isomeric SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCC(=O)O |
| PubChem CID | 6433346 |
| Molecular Weight | 337.5 |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2304323 | Certificate of Analysis | Jan 05, 2023 | L333042 |
| B2304583 | Certificate of Analysis | Jan 05, 2023 | L333042 |
| B2304595 | Certificate of Analysis | Jan 05, 2023 | L333042 |
| B2304646 | Certificate of Analysis | Jan 05, 2023 | L333042 |
| B2304648 | Certificate of Analysis | Jan 05, 2023 | L333042 |