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L-Carnitine hydrochloride - 98%, high purity , CAS No.6645-46-1

≥98%

CAS#: 6645-46-1
Molecular Weight: 197.66
EC Number: 229-663-6
MDL number: MFCD00066100
PubChem CID: 656657
PubChem SID: 488190996

Item Number

C119762

Grouped product items
SKU	Size	Availability	Price
C119762-1g	1g	5	$9.90
C119762-5g	5g	5	$30.90
C119762-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
C119762-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$352.90

Neuromodulator. Antiaging agent.

View related series

Ammonium salt (0) Endogenous Metabolite (0) Metabolic Enzyme/Protease (0) Onium salts (0)

Basic Description

Synonyms	J3Y5E6IKS3 \| L-Carnitine hydrochloride, synthetic, >=98% \| CARNITINE HCL [INCI] \| L-Carnitine chloride \| [(2R)-2,4-bis(oxidanyl)-4-oxidanylidene-butyl]-trimethyl-azanium chloride \| L-Carnitine hydrochloride \| (R)-3-Hydroxy-4-(trimethylammonio)butyrate Hyd
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Naturally occurring substance required in mammalian energy metabolism for facilitating long chain fatty acid transport across mitochondrial membrane. Prevents neurotoxicity. Administration effects dopamine, epinephrine, and serotonin levels.
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488190996
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488190996
IUPAC Name	[(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride
INCHI	InChI=1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1
InChi Key	JXXCENBLGFBQJM-FYZOBXCZSA-N
Canonical SMILES	C[N+](C)(C)CC(CC(=O)O)O.[Cl-]
Isomeric SMILES	C[N+](C)(C)C[C@@H](CC(=O)O)O.[Cl-]
WGK Germany	2
RTECS	BP2979100
PubChem CID	656657
Molecular Weight	197.66
Reaxy-Rn	4301819

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
C1609176	Certificate of Analysis	Oct 08, 2023	C119762
J1519012	Certificate of Analysis	Jun 08, 2023	C119762
B2317419	Certificate of Analysis	Feb 28, 2023	C119762
B2317152	Certificate of Analysis	Feb 28, 2023	C119762
J2229170	Certificate of Analysis	Sep 22, 2022	C119762
J2229179	Certificate of Analysis	Sep 22, 2022	C119762
I1806007	Certificate of Analysis	Jul 12, 2022	C119762

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	BP2979100
Reaxy-Rn	4301819
Merck Index	1849

Reviews

References

1. Isabelle Lelong-Rebel,Christine Brisson,Michel Fabre,Jean-Pierre Bergerat,Gérard Rebel. (2008-04-04) Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line.. Anticancer research, 28 ((1A)): (55-68). [PMID:18383825]
2. Gabriella A Horvath,A G F Davidson,Sylvia G Stockler-Ipsiroglu,Yolanda P Lillquist,Paula J Waters,S Olpin,B S Andresen,Jan Palaty,Judie Nelson,Hilary Vallance. (2008-09-05) Newborn screening for MCAD deficiency: experience of the first three years in British Columbia, Canada.. Canadian journal of public health = Revue canadienne de sante publique, 99 ((4)): (276-280). [PMID:18767270]
3. Joost J Leenders,Wino J Wijnen,Monika Hiller,Ingeborg van der Made,Viola Lentink,Rick E W van Leeuwen,Veronica Herias,Saraswati Pokharel,Stephane Heymans,Leon J de Windt,Morten A Høydal,Yigal M Pinto,Esther E Creemers. (2010-06-23) Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.. The Journal of biological chemistry, 285 ((35)): (27449-27456). [PMID:20566642]
4. Vladimir V Dynnik,Alexey V Kononov,Alexander I Sergeev,Iliya Y Teplov,Arina V Tankanag,Valery P Zinchenko. (2015-07-29) To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?. PloS one, 10 ((7)): (e0134145-e0134145). [PMID:26217943]
5. Silvana Constantinescu,Lorraine P Turcotte. (2015-09-26) Amelioration of palmitate-induced metabolic dysfunction in L6 muscle cells expressing low levels of receptor-interacting protein 140.. Canadian journal of physiology and pharmacology, 93 ((11)): (913-922). [PMID:26406163]
6. R E L Cabral,T B Mendes,V Vendramini,S M Miraglia. (2017-10-04) Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin-treated rats.. Andrology, 6 ((1)): (236-246). [PMID:28973833]
7. Clay O Lacefield,Eftychios A Pnevmatikakis,Liam Paninski,Randy M Bruno. (2019-02-21) Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex.. Cell reports, 26 ((8)): (2000-2008). [PMID:30784583]
8. Johana Vásquez-Procopio,Beatriz Osorio,Leticia Cortés-Martínez,Fidel Hernández-Hernández,Oscar Medina-Contreras,Emmanuel Ríos-Castro,Aram Comjean,Fangge Li,Yanhui Hu,Stephanie Mohr,Norbert Perrimon,Fanis Missirlis. (2019-12-05) Intestinal response to dietary manganese depletion in Drosophila.. Metallomics : integrated biometal science, 12 ((2)): (218-240). [PMID:31799578]
9. Fatima Kazue Okada,Taiza Stumpp,Sandra Maria Miraglia. (2020-04-02) Carnitine Diminishes Etoposide Toxic Action on Spermatogonial Self-renewal and Sperm Production in Adult Rats Treated in the Prepubertal Phase.. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 68 ((5)): (327-342). [PMID:32228279]
10. Holly Brunton,Giuseppina Caligiuri,Richard Cunningham,Rosie Upstill-Goddard,Ulla-Maja Bailey,Ian M Garner,Craig Nourse,Stephan Dreyer,Marc Jones,Kim Moran-Jones,Derek W Wright,Viola Paulus-Hock,Colin Nixon,Gemma Thomson,Nigel B Jamieson,Grant A McGregor,Lisa Evers,Colin J McKay,Aditi Gulati,Rachel Brough,Ilirjana Bajrami,Stephen J Pettitt,Michele L Dziubinski,Simon T Barry,Robert Grützmann,Robert Brown,Edward Curry,Marina Pajic,Elizabeth A Musgrove,Gloria M Petersen,Emma Shanks,Alan Ashworth,Howard C Crawford,Diane M Simeone,Fieke E M Froeling,Christopher J Lord,Debabrata Mukhopadhyay,Christian Pilarsky,Sean E Grimmond,Jennifer P Morton,Owen J Sansom,David K Chang,Peter J Bailey,Andrew V Biankin. (2020-05-14) HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer.. Cell reports, 31 ((6)): (107625-107625). [PMID:32402285]
11. Dries A M Feyen,Wesley L McKeithan,Arne A N Bruyneel,Sean Spiering,Larissa Hörmann,Bärbel Ulmer,Hui Zhang,Francesca Briganti,Michaela Schweizer,Bence Hegyi,Zhandi Liao,Risto-Pekka Pölönen,Kenneth S Ginsburg,Chi Keung Lam,Ricardo Serrano,Christine Wahlquist,Alexander Kreymerman,Michelle Vu,Prashila L Amatya,Charlotta S Behrens,Sara Ranjbarvaziri,Renee G C Maas,Matthew Greenhaw,Daniel Bernstein,Joseph C Wu,Donald M Bers,Thomas Eschenhagen,Christian M Metallo,Mark Mercola. (2020-07-23) Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.. Cell reports, 32 ((3)): (107925-107925). [PMID:32697997]
12. Shumei Miao,Dandan Zhao,Xiaoxiao Wang,Xuan Ni,Xing Fang,Miao Yu,Lingqun Ye,Jingsi Yang,Hongchun Wu,Xinglong Han,Lina Qu,Lei Li,Feng Lan,Zhenya Shen,Wei Lei,Zhen-Ao Zhao,Shijun Hu. (2020-08-31) Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes.. Theranostics, 10 ((21)): (9686-9701). [PMID:32863954]
13. Meng Gao,Yuan Qin,Anqi Li,Sailei Wei,Bilin Liu,Xiangang Tian,Guohua Gong. (2020-09-16) Mitoflash generated at the Qo site of mitochondrial Complex III.. Journal of cellular physiology, 236 ((4)): (2920-2933). [PMID:32930405]
14. Wesley L McKeithan,Dries A M Feyen,Arne A N Bruyneel,Karl J Okolotowicz,Daniel A Ryan,Kevin J Sampson,Franck Potet,Alex Savchenko,Jorge Gómez-Galeno,Michelle Vu,Ricardo Serrano,Alfred L George,Robert S Kass,John R Cashman,Mark Mercola. (2020-09-16) Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.. Cell stem cell, 27 ((5)): (813-821). [PMID:32931730]
15. Merve Yaşacan,Açelya Erikçi,Cemil Can Eylem,Samiye Yabanoğlu Çiftçi,Emirhan Nemutlu,Kezban Ulubayram,İpek Eroğlu. (2020-11-07) Polymeric Nanoparticle Versus Liposome Formulations: Comparative Physicochemical and Metabolomic Studies as L-Carnitine Delivery Systems.. AAPS PharmSciTech, 21 ((8)): (308-308). [PMID:33156405]
16. Takehito Okui,Masaya Iwashita,Maximillian A Rogers,Arda Halu,Samantha K Atkins,Shiori Kuraoka,Ilyes Abdelhamid,Hideyuki Higashi,Ashisha Ramsaroop,Masanori Aikawa,Sasha A Singh,Elena Aikawa. (2020-12-29) CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.. Arteriosclerosis, thrombosis, and vascular biology, 41 ((2)): (755-768). [PMID:33356393]
17. Junichi Suzuki. (2021-03-03) Effects of hyperbaric environment on endurance and metabolism are exposure time-dependent in well-trained mice.. Physiological reports, 9 ((5)): (e14780-e14780). [PMID:33650813]
18. Andrea S Pereyra,Kate L Harris,Arvin H Soepriatna,Quin A Waterbury,Sivakama S Bharathi,Yuxun Zhang,Kelsey H Fisher-Wellman,Craig J Goergen,Eric S Goetzman,Jessica M Ellis. (2021-03-25) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency.. Journal of lipid research, 62 (100069-100069). [PMID:33757734]
19. Manuel A González Hernández,Ellen E Blaak,Nicole T H Hoebers,Yvonne P G Essers,Emanuel E Canfora,Johan W E Jocken. (2021-07-06) Acetate Does Not Affect Palmitate Oxidation and AMPK Phosphorylation in Human Primary Skeletal Muscle Cells.. Frontiers in endocrinology, 12 (659928-659928). [PMID:34220709]
20. Sarah Krantz,Young-Mee Kim,Shubhi Srivastava,Joseph W Leasure,Peter T Toth,Glenn Marsboom,Jalees Rehman. (2021-11-18) Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation.. The Journal of biological chemistry, 297 ((6)): (101410-101410). [PMID:34785214]
21. Andreas Schulze,Christiane Schmidt,Dirk Kohlmüller,Georg F Hoffmann,Ertan Mayatepek. (2003-08-21) Accurate measurement of free carnitine in dried blood spots by isotope-dilution electrospray tandem mass spectrometry without butylation.. Clinica chimica acta; international journal of clinical chemistry, 335 ((1-2)): (137-145). [PMID:12927695]
22. R E L Cabral,F K Okada,T Stumpp,V Vendramini,S M Miraglia. (2014-10-02) Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre-puberty.. Andrology, 2 ((6)): (931-942). [PMID:25270029]
23. Jenna L Lowe,Roslyn Bathgate,Christopher G Grupen. (2019-05-02) Effect of carbohydrates on lipid metabolism during porcine oocyte IVM.. Reproduction, fertility, and development, 31 ((3)): (557-569). [PMID:31039975]
24. Giulia Mollica,Pamela Senesi,Roberto Codella,Fernanda Vacante,Anna Montesano,Livio Luzi,Ileana Terruzzi. (2019-10-15) L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 52 ((3)): (314-323). [PMID:31607566]
25. Satish Kumar Tiwari,Ashish Ganeshlalji Toshniwal,Sudip Mandal,Lolitika Mandal. (2020-06-13) Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila.. eLife, 9 [PMID:32530419]
26. Carmen Escalona-Garrido,Patricia Vázquez,Paula Mera,Sebastián Zagmutt,Ester García-Casarrubios,Ana Montero-Pedrazuela,Fernanda Rey-Stolle,Ana Guadaño-Ferraz,Francisco J Rupérez,Dolors Serra,Laura Herrero,Maria Jesus Obregon,Ángela M Valverde. (2020-10-14) Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.. Molecular metabolism, 42 (101097-101097). [PMID:33049408]
27. Jing Han,Hongbo Qu,Mingli Han,Yichao Ding,Mingwei Xie,Jianguo Hu,Yuanwen Chen,Huaying Dong. (2020-12-05) MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer.. Oncogene, 40 ((4)): (833-847). [PMID:33273726]

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