L-α-Lysophosphatidylcholine (from egg yolk) - ≥99%, Type I, powder, high purity , CAS No.9008-30-4, Activator of ASIC3;Activator of K 2P10.1;Activator of TRPC5;Activator of TRPC6;Activator of TRPV2

Item Number

L339698

• Synonyms: GTPL2508 | Lysophosphatidylcholine, soybean | Lysophosphatidylcholine | [(2R)-3-acetyloxy-2-hydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | [(2R)-3-acetyloxy-2-hydroxypropyl] 2-trimethylazaniumylethyl phosphate | UNII-CQD833204Z | Q27083304 | CQD83
• Specifications & Purity: Moligand™, ≥99%, Type I, powder
• Biochemical and Physiological Mechanisms: Lysophosphatidylcholine is a major component of oxidized low density lipoprotein and is associated with a variety of inflammatory responses including atherosclerosis. To demyelinate neurons in the spinal cord and to study the processes that underlie myeli
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR
• Mechanism of action: Activator of ASIC3;Activator of K 2P10.1;Activator of TRPC5;Activator of TRPC6;Activator of TRPV2

Product Description

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.