JNK-IN-8 - ≥98%, high purity , CAS No.1410880-22-6, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Item Number

J125321

Grouped product items
SKU	Size	Availability	Price
J125321-5mg	5mg	2	$86.90
J125321-10mg	10mg	1	$147.90
J125321-25mg	25mg	2	$333.90
J125321-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$439.90
J125321-100mg	100mg	1	$731.90

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Basic Description

Synonyms	JNK Inhibitor XVI \| CHEBI:124918 \| 3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide \| 3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide \| 3
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9
Product Description	JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line. A selective and irreversible type 2 inhibitor of JNK

Names and Identifiers

Pubchem Sid	504771553
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771553
IUPAC Name	3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
INCHI	InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
InChi Key	GJFCSAPFHAXMSF-UXBLZVDNSA-N
Canonical SMILES	CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
Isomeric SMILES	CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)/C=C/CN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
PubChem CID	57340686
Molecular Weight	507.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
G2213069	Certificate of Analysis	Apr 07, 2024	J125321
G2213107	Certificate of Analysis	Apr 07, 2024	J125321
G2213108	Certificate of Analysis	Apr 07, 2024	J125321
G2213109	Certificate of Analysis	Apr 07, 2024	J125321
G2213110	Certificate of Analysis	Apr 07, 2024	J125321
G2213001	Certificate of Analysis	Jun 05, 2022	J125321

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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Basic Description