| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| J650902-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $240.90 | |
| J650902-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $540.90 |
| Synonyms | EX-A5812 | DTXSID10402359 | NSC98003 | NSC-98003 | HY-137924 | CS-0142930 | SCHEMBL24559257 | JA2131 | 1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one |
|---|---|
| Specifications & Purity | ≥99% |
| Biochemical and Physiological Mechanisms | JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) ( IC 50 =0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) ( IC 50 =0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death. In Vitro JA2131 (10 mM; 1-2 h) induces hyperPARylation of PARP1 in PC3 cells. JA2131 (10 μM; 2 wk) inhibits colony formation of MCF-7, PC3, and MDA-MB-231 cells, and (0.1 μM-1 mM; 72 h) shows cytotoxicity to inhibit MRC-50 cells with an IC 50 value of 132 μM. JA2131 (5 μM; 72 h) inhibits PC3, and A172 glioblastoma cells viability. JA2131 (10 μM; 2 h) could be acting at the replication fork in HeLa cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: PC3, and A172 glioblastoma cells Concentration: 0.1 μM-10 mM Incubation Time: 72 hours Result: Inhibited cell viability with IC50s of 33.05 μM (PC3 cells) and 55.34 μM (A172 cells), respectively. Form:Solid |
| IUPAC Name | 1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one |
|---|---|
| INCHI | InChI=1S/C13H19N5O2S2/c1-16-10-9(11(21)17(2)13(16)19)14-12(15-10)22-8-5-18-3-6-20-7-4-18/h3-8H2,1-2H3,(H,14,15) |
| InChi Key | XHNSOGDMSSHQFY-UHFFFAOYSA-N |
| Canonical SMILES | CN1C2=C(C(=S)N(C1=O)C)NC(=N2)SCCN3CCOCC3 |
| Isomeric SMILES | CN1C2=C(C(=S)N(C1=O)C)NC(=N2)SCCN3CCOCC3 |
| Alternate CAS | 6505-99-3 |
| PubChem CID | 4361023 |
| NSC Number | 98003 |
| Molecular Weight | 341.45 |
