| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| I422440-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $76.90 |
Cell-permeable HDAC activator. Selective Trichostatin A suppressor.
| Synonyms | ITSA-1 | 200626-61-5 | ITSA1 | N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide | ITSA-1 (ITSA1) | benzotriazol-1-yl-(2,4-dichlorophenyl)methanone | (1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone | CHEBI:75330 | 1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Cell-permeable HDAC activator. Selective Trichostatin A suppressor. Counteracts Trichostatin A-induced cell cycle arrest. Inhibits Trichostatin A-induced tubulin acetylation. Shows no effect on the activity of other HDAC inhibitors. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Product introduction： ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | benzotriazol-1-yl-(2,4-dichlorophenyl)methanone |
|---|---|
| INCHI | InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H |
| InChi Key | UVNLAUGZMOPBPR-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl |
| Isomeric SMILES | C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl |
| PubChem CID | 771910 |
| Molecular Weight | 292.12 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H302:Harmful if swallowed |
| Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
